Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population

E. W. Loh; N. L.S. Tang; D. T.S. Lee; S. I. Liu; Alfreda Stadlin

doi:10.1002/ajmg.b.30429

Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population

E. W. Loh, N. L.S. Tang, D. T.S. Lee, S. I. Liu, Alfreda Stadlin

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

GABA_A receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABA_A receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABA_Aγ2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed.

Original language	English
Pages (from-to)	439-443
Number of pages	5
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	144
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.b.30429
Publication status	Published - Jun 5 2007
Externally published	Yes

Keywords

5q33
Chinese
GABA receptor subunit gene
Heroin dependence
Single nucleotide polymorphism

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/ajmg.b.30429

Cite this

@article{8ade72f2452f44d294720b6b85d94f6b,

title = "Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population",

abstract = "GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAγ2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed.",

keywords = "5q33, Chinese, GABA receptor subunit gene, Heroin dependence, Single nucleotide polymorphism",

author = "Loh, {E. W.} and Tang, {N. L.S.} and Lee, {D. T.S.} and Liu, {S. I.} and Alfreda Stadlin",

note = "Funding Information: This systematic review was funded by the Deputy Vice‐Chancellor Indigenous Strategy and Services at The University of Sydney. Such a review is needed to inform any proposed curriculum renewal process in the future and contributes a basis for accountability and assurance of the standards of teaching and learning experiences in all dental faculty programs.",

year = "2007",

month = jun,

day = "5",

doi = "10.1002/ajmg.b.30429",

language = "English",

volume = "144",

pages = "439--443",

journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",

issn = "1552-4841",

publisher = "Wiley-Liss Inc.",

number = "4",

}

TY - JOUR

T1 - Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population

AU - Loh, E. W.

AU - Tang, N. L.S.

AU - Lee, D. T.S.

AU - Liu, S. I.

AU - Stadlin, Alfreda

N1 - Funding Information: This systematic review was funded by the Deputy Vice‐Chancellor Indigenous Strategy and Services at The University of Sydney. Such a review is needed to inform any proposed curriculum renewal process in the future and contributes a basis for accountability and assurance of the standards of teaching and learning experiences in all dental faculty programs.

PY - 2007/6/5

Y1 - 2007/6/5

N2 - GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAγ2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed.

AB - GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAγ2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed.

KW - 5q33

KW - Chinese

KW - GABA receptor subunit gene

KW - Heroin dependence

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=34250801588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250801588&partnerID=8YFLogxK

U2 - 10.1002/ajmg.b.30429

DO - 10.1002/ajmg.b.30429

M3 - Article

C2 - 17440936

AN - SCOPUS:34250801588

SN - 1552-4841

VL - 144

SP - 439

EP - 443

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

IS - 4

ER -

Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this