Associating acrylamide internal exposure with dietary pattern and health risk in the general population of Taiwan

Kai Wei Liao; Fang Chi Chang; Chia Huang Chang; Yu Fang Huang; Wen Harn Pan; Mei Lien Chen

doi:10.1016/j.foodchem.2021.131653

Associating acrylamide internal exposure with dietary pattern and health risk in the general population of Taiwan

Kai Wei Liao, Fang Chi Chang, Chia Huang Chang, Yu Fang Huang, Wen Harn Pan, Mei Lien Chen

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We determined the urinary levels of acrylamide (AA) metabolites of the general Taiwanese population, explore the association between AA internal exposure and dietary intake frequency, and assess the health risk. Urine samples and dietary questionnaires were collected from the subjects of the Nutrition and Health Survey in Taiwan. AA metabolite [N-acetyl-S-(propionamide)-cysteine (AAMA)] concentrations were analyzed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-ToF-MS). Multiple regression was used to examine associations between AA metabolite levels and dietary patterns. A total of 706 subjects were studied. We found that per increase in weekly frequency of sweetened beverages in the 6–11-years group (β = 0.322, p = 0.018) and oily snacks intakes in the 12–18-years group (β = 0.335, p = 0.012) will increase 10^β of urinary AAMA concentrations. Assuming that 50% of the AA intake is excreted as urinary AAMA, the Monte Carlo simulation showed that 1.75–19.48% among all age groups have exceeded the reference dose of 2 μg/kg-body weight/day.

Original language	English
Article number	131653
Journal	Food Chemistry
Volume	374
DOIs	https://doi.org/10.1016/j.foodchem.2021.131653
Publication status	Published - Apr 16 2022

Keywords

Acrylamide
Dietary pattern
Health risk assessment
Human biomonitoring
N-acetyl-S-(propionamide)-cysteine
Taiwan

ASJC Scopus subject areas

Analytical Chemistry
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2021.131653

Cite this

@article{0e07b619b9664dcab948eb3a18892013,

title = "Associating acrylamide internal exposure with dietary pattern and health risk in the general population of Taiwan",

abstract = "We determined the urinary levels of acrylamide (AA) metabolites of the general Taiwanese population, explore the association between AA internal exposure and dietary intake frequency, and assess the health risk. Urine samples and dietary questionnaires were collected from the subjects of the Nutrition and Health Survey in Taiwan. AA metabolite [N-acetyl-S-(propionamide)-cysteine (AAMA)] concentrations were analyzed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-ToF-MS). Multiple regression was used to examine associations between AA metabolite levels and dietary patterns. A total of 706 subjects were studied. We found that per increase in weekly frequency of sweetened beverages in the 6–11-years group (β = 0.322, p = 0.018) and oily snacks intakes in the 12–18-years group (β = 0.335, p = 0.012) will increase 10β of urinary AAMA concentrations. Assuming that 50% of the AA intake is excreted as urinary AAMA, the Monte Carlo simulation showed that 1.75–19.48% among all age groups have exceeded the reference dose of 2 μg/kg-body weight/day.",

keywords = "Acrylamide, Dietary pattern, Health risk assessment, Human biomonitoring, N-acetyl-S-(propionamide)-cysteine, Taiwan",

author = "Liao, {Kai Wei} and Chang, {Fang Chi} and Chang, {Chia Huang} and Huang, {Yu Fang} and Pan, {Wen Harn} and Chen, {Mei Lien}",

note = "Funding Information: This work was supported by the Ministry of Science and Technology (Grant No.: MOST 106-3114-B-010-001 and 107-2321-B-010-006) and by Taiwan Food and Drug Administration, Ministry of Health and Welfare (Grant NO.: DOH94-FS-6-4, DOH99-FDA-31014, DOH100-FDA-31014, DOH101-FDA-31411). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

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doi = "10.1016/j.foodchem.2021.131653",

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T1 - Associating acrylamide internal exposure with dietary pattern and health risk in the general population of Taiwan

AU - Liao, Kai Wei

AU - Chang, Fang Chi

AU - Chang, Chia Huang

AU - Huang, Yu Fang

AU - Pan, Wen Harn

AU - Chen, Mei Lien

N1 - Funding Information: This work was supported by the Ministry of Science and Technology (Grant No.: MOST 106-3114-B-010-001 and 107-2321-B-010-006) and by Taiwan Food and Drug Administration, Ministry of Health and Welfare (Grant NO.: DOH94-FS-6-4, DOH99-FDA-31014, DOH100-FDA-31014, DOH101-FDA-31411). Publisher Copyright: © 2021 Elsevier Ltd

PY - 2022/4/16

Y1 - 2022/4/16

N2 - We determined the urinary levels of acrylamide (AA) metabolites of the general Taiwanese population, explore the association between AA internal exposure and dietary intake frequency, and assess the health risk. Urine samples and dietary questionnaires were collected from the subjects of the Nutrition and Health Survey in Taiwan. AA metabolite [N-acetyl-S-(propionamide)-cysteine (AAMA)] concentrations were analyzed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-ToF-MS). Multiple regression was used to examine associations between AA metabolite levels and dietary patterns. A total of 706 subjects were studied. We found that per increase in weekly frequency of sweetened beverages in the 6–11-years group (β = 0.322, p = 0.018) and oily snacks intakes in the 12–18-years group (β = 0.335, p = 0.012) will increase 10β of urinary AAMA concentrations. Assuming that 50% of the AA intake is excreted as urinary AAMA, the Monte Carlo simulation showed that 1.75–19.48% among all age groups have exceeded the reference dose of 2 μg/kg-body weight/day.

AB - We determined the urinary levels of acrylamide (AA) metabolites of the general Taiwanese population, explore the association between AA internal exposure and dietary intake frequency, and assess the health risk. Urine samples and dietary questionnaires were collected from the subjects of the Nutrition and Health Survey in Taiwan. AA metabolite [N-acetyl-S-(propionamide)-cysteine (AAMA)] concentrations were analyzed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-ToF-MS). Multiple regression was used to examine associations between AA metabolite levels and dietary patterns. A total of 706 subjects were studied. We found that per increase in weekly frequency of sweetened beverages in the 6–11-years group (β = 0.322, p = 0.018) and oily snacks intakes in the 12–18-years group (β = 0.335, p = 0.012) will increase 10β of urinary AAMA concentrations. Assuming that 50% of the AA intake is excreted as urinary AAMA, the Monte Carlo simulation showed that 1.75–19.48% among all age groups have exceeded the reference dose of 2 μg/kg-body weight/day.

KW - Acrylamide

KW - Dietary pattern

KW - Health risk assessment

KW - Human biomonitoring

KW - N-acetyl-S-(propionamide)-cysteine

KW - Taiwan

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SN - 0308-8146

VL - 374

JO - Food Chemistry

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ER -

Associating acrylamide internal exposure with dietary pattern and health risk in the general population of Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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