Assessment of High Risk for Alzheimer's Disease Using Plasma Biomarkers in Subjects with Normal Cognition in Taiwan: A Preliminary Study

Chaur Jong Hu, Ming Jang Chiu, Ming Chyi Pai, Sui Hing Yan, Pei Ning Wang, Pai Yi Chiu, Chin Hsien Lin, Ta Fu Chen, Fu Chi Yang, Kuo Lun Huang, Yi Ting Hsu, Yi Chou Hou, Wei Che Lin, Cheng Hsien Lu, Li Kai Huang, Shieh Yueh Yang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background: In Alzheimer's disease (AD), cognitive impairment begins 10-15 years later than neurodegeneration in the brain. Plasma biomarkers are promising candidates for assessing neurodegeneration in people with normal cognition. It has been reported that subjects with the concentration of plasma amyloid-β 1-42×total tau protein higher than 455 pg2/ml2 are assessed as having a high risk of amnesic mild impairment or AD, denoted as high risk of AD (HRAD). Objective: The prevalence of high-risk for dementia in cognitively normal controls is explored by assaying plasma biomarkers. Methods: 422 subjects with normal cognition were enrolled around Taiwan. Plasma Aβ1-40, Aβ1-42, and T-Tau levels were assayed using immunomagnetic reduction to assess the risk of dementia. Results: The results showed that 4.6% of young adults (age: 20-44 years), 8.5% of middle-aged adults (age: 45-64 years), and 7.3% of elderly adults (age: 65-90 years) had HRAD. The percentage of individuals with HRAD dramatically increased in middle-aged and elderly adults compared to young adults. Conclusion: The percentage of HRAD in cognitively normal subjects are approximately 10%, which reveals that the potentially public-health problem of AD in normal population. Although the subject having abnormal levels of Aβ or tau is not definitely going on to develop cognitive declines or AD, the risk of suffering cognitive impairment in future is relatively high. Suitable managements are suggested for these high-risk cognitively normal population. Worth noting, attention should be paid to preventing cognitive impairment due to AD, not only in elderly adults but also middle-aged adults.

Original languageEnglish
Pages (from-to)761-770
Number of pages10
JournalJournal of Alzheimer's Disease Reports
Issue number1
Publication statusPublished - 2021


  • Alzheimer's disease
  • immunomagnetic reduction
  • normal cognition
  • plasma biomarkers

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Clinical Psychology


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