Assessing suitability of co@au core/shell nanoparticle geometry for improved theranostics in colon carcinoma

Udesh Dhawan, Ching Li Tseng, Huey Yuan Wang, Shin Yun Hsu, Meng Tsan Tsai, Ren Jei Chung

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size. However, little is known about the effect of nanomaterial geometry on cell behavior. To elucidate this and to extend the application in cancer theranostics, we have engineered core–shell cobalt– gold nanoparticles with spherical (Co@Au NPs) and elliptical morphology (Co@Au NEs). Our results show that owing to superparamagnetism, Co@Au NPs can generate hyperthermia upon magnetic field stimulation. In contrast, due to the geometric difference, Co@Au NEs can be optically excited to generate hyperthermia upon photostimulation and elevate the medium temperature to 45 °C. Both nanomaterial geometries can be employed as prospective contrast agents; however, at identical concentration, Co@Au NPs exhibited 4-fold higher cytotoxicity to L929 fibroblasts as compared to Co@Au NEs, confirming the effect of nanomaterial geometry on cell fate. Furthermore, photostimulation-generated hyperthermia prompted detachment of anti-cancer drug, Methotrexate (MTX), from Co@Au NEs-MTX complex and which triggered 90% decrease in SW620 colon carcinoma cell viability, confirming their application in cancer theranostics. The geometry-based perturbation of cell fate can have a profound impact on our understanding of interactions at nano-bio interface which can be exploited for engineering materials with optimized geometries for superior theranostic applications.

Original languageEnglish
Article number2048
Issue number8
Publication statusPublished - Aug 2021


  • Cobalt–gold
  • Colon carcinoma
  • Core–shell
  • Hyperthermia
  • Methotrexate
  • Nanoparticles

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Materials Science


Dive into the research topics of 'Assessing suitability of co@au core/shell nanoparticle geometry for improved theranostics in colon carcinoma'. Together they form a unique fingerprint.

Cite this