Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

Hsiu Chen Lin; Yung Kai Huang; Horng Sheng Shiue; Liang Sien Chen; Cheuk-Sing Choy; Shiau Rung Huang; Bor Cheng Han; Yu Mei Hsueh

doi:10.1016/j.fct.2014.08.018

Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

Hsiu Chen Lin, Yung Kai Huang, Horng Sheng Shiue, Liang Sien Chen, Cheuk-Sing Choy, Shiau Rung Huang, Bor Cheng Han, Yu Mei Hsueh

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMA^V) and dimethylarsinic acid (DMA^V) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMA^V percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.

Original language	English
Pages (from-to)	60-67
Number of pages	8
Journal	Food and Chemical Toxicology
Volume	74
DOIs	https://doi.org/10.1016/j.fct.2014.08.018
Publication status	Published - Dec 1 2014

Keywords

Adolescents
Arsenic methylation capability
HOMA-IR
Insulin resistance
Obesity

ASJC Scopus subject areas

Food Science
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fct.2014.08.018

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@article{3339c82f78a342658d8a3448d851185d,

title = "Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents",

abstract = "The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMAV percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.",

keywords = "Adolescents, Arsenic methylation capability, HOMA-IR, Insulin resistance, Obesity",

author = "Lin, {Hsiu Chen} and Huang, {Yung Kai} and Shiue, {Horng Sheng} and Chen, {Liang Sien} and Cheuk-Sing Choy and Huang, {Shiau Rung} and Han, {Bor Cheng} and Hsueh, {Yu Mei}",

note = "Funding Information: The study was supported by grants from the Taipei Medical University Hospital ( 99TMU-TMUH-02-3 ) and the National Science Council Taiwan (NSC 100-2314-B-038 -026 , and NSC 101-2314-B-038-051-MY3 ) (1–3). We appreciate the assistance from the team led by Professor Chiou Hung-Yi in the recruitment of study subjects. All authors have disclosed any potential competing financial interests regarding the submitted article. Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.fct.2014.08.018",

language = "English",

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T1 - Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

AU - Lin, Hsiu Chen

AU - Huang, Yung Kai

AU - Shiue, Horng Sheng

AU - Chen, Liang Sien

AU - Choy, Cheuk-Sing

AU - Huang, Shiau Rung

AU - Han, Bor Cheng

AU - Hsueh, Yu Mei

N1 - Funding Information: The study was supported by grants from the Taipei Medical University Hospital ( 99TMU-TMUH-02-3 ) and the National Science Council Taiwan (NSC 100-2314-B-038 -026 , and NSC 101-2314-B-038-051-MY3 ) (1–3). We appreciate the assistance from the team led by Professor Chiou Hung-Yi in the recruitment of study subjects. All authors have disclosed any potential competing financial interests regarding the submitted article. Publisher Copyright: © 2014 Elsevier Ltd.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMAV percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.

AB - The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMAV percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.

KW - Adolescents

KW - Arsenic methylation capability

KW - HOMA-IR

KW - Insulin resistance

KW - Obesity

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SN - 0278-6915

VL - 74

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EP - 67

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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