The metabolism of inorganic arsenic takes place through a series of reactions, including reduction and oxidative methylation reactions. Biomethylation is considered a major detoxification pathway for inorganic arsenic. However, interspecies differences exist according to the efficiency with which inorganic arsenic is metabolized and excreted in urine. Intermediate trivalent methylated arsenic species are more cytotoxic and genotoxic than inorganic compounds. The arsenic methylation profile is influenced by demographic characteristics, lifestyle, diet and genetic susceptibility. Inefficient methylation is related to the risk of cancer and noncancer disease.
|Title of host publication||Health Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic|
|Publisher||World Scientific Publishing Co.|
|Number of pages||20|
|ISBN (Print)||9814291811, 9789814291811|
|Publication status||Published - Jan 1 2011|
ASJC Scopus subject areas
- Environmental Science(all)