TY - GEN
T1 - Arsenic, DNA damage, and cancers of bladder and kidney – a long-term follow-up of residents in arseniasis endemic area of north-eastern Taiwan
AU - Wang, S. L.
AU - Tsai, S. F.
AU - Hsu, L. I.
AU - Chen, C. J.
AU - Hsu, K. H.
AU - Chiou, H. Y.
N1 - Publisher Copyright:
© 2018, CRC Press/Balkema. All rights reserved.
PY - 2018
Y1 - 2018
N2 - The aim is to assess dose-response association between arsenic exposure, DNA damage biomarkers, and the incidence of bladder and kidney cancers. A total of 8102 men and women from 3901 households have been enrolled in 1991–1994, and followed in 2011–2014. The data collected included well water consumption, habits of cigarette smoking, alcohol consumption, exercise and diet, through standardized personal interview. The individual urinary arsenic species were quantified using high-performance liquid chromatography–inductively coupled plasma/mass spectrometry (HPLC-ICP/MS). For assessment of oxidative and methylated DNA lesions and depletion, urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and N7-methylguanine (N7-MeG) were measured respectively, using liquid chromatography/tandem mass spectrometry (LC-MS/MS). The National Cancer Registry Data using the pathology finding defined bladder and kidney cancers. Urinary levels of the two DNA adduct increased significantly with increasing urinary arsenic level (iAs+MMA+DMA) in both men (β = 0.82, β = 0.34 for 8-oxodG and N7-MeG, respectively, p < 0.0001 for both) and women (β = 1.03, 0.38, p < 0.0001) adjusted for potential confounders. Incidence rate of bladder and kidney cancer using person-years tended to be the highest for higher urinary inorganic and methylated arsenic with higher DNA adduct level than the medians. It is suggested that subjects with high arsenic exposure experienced further cancer risk with high level of DNA damage biomarker.
AB - The aim is to assess dose-response association between arsenic exposure, DNA damage biomarkers, and the incidence of bladder and kidney cancers. A total of 8102 men and women from 3901 households have been enrolled in 1991–1994, and followed in 2011–2014. The data collected included well water consumption, habits of cigarette smoking, alcohol consumption, exercise and diet, through standardized personal interview. The individual urinary arsenic species were quantified using high-performance liquid chromatography–inductively coupled plasma/mass spectrometry (HPLC-ICP/MS). For assessment of oxidative and methylated DNA lesions and depletion, urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and N7-methylguanine (N7-MeG) were measured respectively, using liquid chromatography/tandem mass spectrometry (LC-MS/MS). The National Cancer Registry Data using the pathology finding defined bladder and kidney cancers. Urinary levels of the two DNA adduct increased significantly with increasing urinary arsenic level (iAs+MMA+DMA) in both men (β = 0.82, β = 0.34 for 8-oxodG and N7-MeG, respectively, p < 0.0001 for both) and women (β = 1.03, 0.38, p < 0.0001) adjusted for potential confounders. Incidence rate of bladder and kidney cancer using person-years tended to be the highest for higher urinary inorganic and methylated arsenic with higher DNA adduct level than the medians. It is suggested that subjects with high arsenic exposure experienced further cancer risk with high level of DNA damage biomarker.
UR - http://www.scopus.com/inward/record.url?scp=85079212701&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079212701&partnerID=8YFLogxK
U2 - 10.1201/9781351046633-125
DO - 10.1201/9781351046633-125
M3 - Conference contribution
AN - SCOPUS:85079212701
SN - 9781138486096
T3 - Environmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018
SP - 317
EP - 318
BT - Environmental Arsenic in a ChangingWorld - 7th International Congress and Exhibition Arsenic in the Environment, 2018
A2 - Zhu, Yong-Guan
A2 - Zhu, Yong-Guan
A2 - Guo, Huaming
A2 - Guo, Huaming
A2 - Bhattacharya, Prosun
A2 - Bhattacharya, Prosun
A2 - Bundschuh, Jochen
A2 - Ahmad, Arslan
A2 - Ahmad, Arslan
A2 - Ahmad, Arslan
A2 - Naidu, Ravi
A2 - Naidu, Ravi
PB - CRC Press/Balkema
T2 - 7th International Congress and Exhibition Arsenic in the Environment, 2018
Y2 - 1 July 2018 through 6 July 2018
ER -