Abstract
Arsenic-induced atherogenicity has been well documented. Morbidity of ischemic heart disease was examined among residents in the blackfoot disease-endemic area in southwestern Taiwan to explore the relationship between long-term arsenic exposure and ischemic heart disease. A total of 78 prevalent cases of electrocardiogram-diagnosed ischemic heart disease identified from a community-based surrey and 384 age-sex-matched healthy controls were included. Multiple logistic regression analysis showed a statistically significant association of ischemic heart disease with long-term arsenic exposure. After adjustment for age, sex, hypertension, diabetes mellitus, ratio of total cholesterol to high-density lipoprotein cholesterol, body mass index, and alcohol consumption, the odds ratio of developing ischemic heart disease was 1.60 and 3.60, respectively, for those who had a cumulative arsenic exposure of 0.1-14.9 and ＞=15.0ppm-years compared with those who had no exposure to arsenic through drinking water. Arsenic is an important and independent risk factor for ischemic heart disease in the blackfoot disease-endemic area.
| Translated title of the contribution | Arsenic and Ischemic Heart Disease in the Blackfoot Disease-Endemic Area |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 502-511 |
| Number of pages | 10 |
| Journal | Chinese Journal of Public Health |
| Volume | 14 |
| Issue number | 6 |
| Publication status | Published - Dec 1 1995 |
Keywords
- 砷
- 缺血性心臟病
- 病例對照研究
- Arsenic
- Ischemic Heart Disease
- Case-Control Study
