Abstract
Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p
Original language | English |
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Pages (from-to) | 832-837 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 423 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 13 2012 |
Keywords
- Advanced glycation end products
- Aristolochic acid
- Aristolochic acid nephropathy
- Glutathione
- Methylglyoxal
- N -(carboxymethyl)lysine
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology