TY - JOUR
T1 - Arenarosides A-G, Polyhydroxylated Oleanane-Type Saponins from Polycarpaea arenaria and their Cytotoxic and Antiangiogenic Activities
AU - Nguyen, Nham Linh
AU - Vo, Thanh Hoa
AU - Lin, Yu Chi
AU - Liaw, Chia Ching
AU - Lu, Mei Kuang
AU - Cheng, Jing Jy
AU - Chen, Mei Chuan
AU - Kuo, Yao Haur
N1 - Funding Information:
This work was supported by grants from the Ministry of Health and Welfare (New Southbound Policy-NRICM-NSP-108-01, NRICM-NSP-109-01) and the Ministry of Science and Technology (MOST104-2320-B-077-006-MY3, MOST107-2320-B-077-003-MY3), Taiwan. The authors would like to thank Professor Chien-Chang Shen, National Research Institute of Chinese Medicine, for his assistance in the English improvement of the manuscript.
Publisher Copyright:
©
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2/26
Y1 - 2021/2/26
N2 - Seven new polyhydroxylated oleanane-type triterpene saponins, arenarosides A-G (1-7), together with four known compounds, were isolated from an ethanol extract of the aerial parts of the Vietnamese plant Polycarpaea arenaria. The chemical structures of the newly isolated oleanane saponins were elucidated on the basis of spectroscopic and spectrometric analysis, especially 2D NMR and HRMS. Biological evaluation revealed that 3, 4, 6, and 7 showed moderate activities against four human cancer cell lines (A549, HTC116, PC3, and RT112) with IC50 values of 6.0-9.9 μM, and 3, 4, 5, and 7 also displayed promising antiangiogenesis effects with IC50 values <5 μM in the test system used. Among the isolates, arenaroside D (4) exhibited the most potent inhibitory effects, not only in cancer cell proliferation but also in angiogenic activities. Preliminary SAR studies revealed that the presence of an acetyl group at C-22 in oleanane-type triterpene saponins increases these bioactivities.
AB - Seven new polyhydroxylated oleanane-type triterpene saponins, arenarosides A-G (1-7), together with four known compounds, were isolated from an ethanol extract of the aerial parts of the Vietnamese plant Polycarpaea arenaria. The chemical structures of the newly isolated oleanane saponins were elucidated on the basis of spectroscopic and spectrometric analysis, especially 2D NMR and HRMS. Biological evaluation revealed that 3, 4, 6, and 7 showed moderate activities against four human cancer cell lines (A549, HTC116, PC3, and RT112) with IC50 values of 6.0-9.9 μM, and 3, 4, 5, and 7 also displayed promising antiangiogenesis effects with IC50 values <5 μM in the test system used. Among the isolates, arenaroside D (4) exhibited the most potent inhibitory effects, not only in cancer cell proliferation but also in angiogenic activities. Preliminary SAR studies revealed that the presence of an acetyl group at C-22 in oleanane-type triterpene saponins increases these bioactivities.
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U2 - 10.1021/acs.jnatprod.0c00919
DO - 10.1021/acs.jnatprod.0c00919
M3 - Article
AN - SCOPUS:85100251839
SN - 0163-3864
VL - 84
SP - 259
EP - 267
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -
