Areca nut may kill cells in a different way

Mei Huei Lin; Shyun Yeu Liu; Young Chau Liu

Areca nut may kill cells in a different way

Mei Huei Lin, Shyun Yeu Liu, Young Chau Liu

School of Dentistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Areca nut (AN, Areca catechu L.) is a popular but carcinogenic chewing material used by approximately 200-600 million people worldwide. In the past few decades, AN has been discovered to possess genotoxic, cytostatic, and cytotoxic effects on cells. Some ingredients of AN, such as AN extract (ANE), arecoline, hydroxychavicol, and oligomeric procyanidins were demonstrated to stimulate apoptotic and/or growth arresting phenotypes in treated cells. However, our recent studies showed that ANE predominantly induces the autophagic responses, albeit the simultaneous initiation of apoptotic pathway. This finding may renew the knowledge about the cytotoxic effects of AN on oral cells in physiological conditions.

Original language	English
Title of host publication	Nuts: Properties, Consumption and Nutrition
Subtitle of host publication	Properties, Consumption and Nutrition
Publisher	Nova Science Publishers Inc
Pages	167-172
Number of pages	6
ISBN (Print)	9781617619786
Publication status	Published - 2011

ASJC Scopus subject areas

General Agricultural and Biological Sciences

Cite this

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title = "Areca nut may kill cells in a different way",

abstract = "Areca nut (AN, Areca catechu L.) is a popular but carcinogenic chewing material used by approximately 200-600 million people worldwide. In the past few decades, AN has been discovered to possess genotoxic, cytostatic, and cytotoxic effects on cells. Some ingredients of AN, such as AN extract (ANE), arecoline, hydroxychavicol, and oligomeric procyanidins were demonstrated to stimulate apoptotic and/or growth arresting phenotypes in treated cells. However, our recent studies showed that ANE predominantly induces the autophagic responses, albeit the simultaneous initiation of apoptotic pathway. This finding may renew the knowledge about the cytotoxic effects of AN on oral cells in physiological conditions.",

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AU - Lin, Mei Huei

AU - Liu, Shyun Yeu

AU - Liu, Young Chau

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N2 - Areca nut (AN, Areca catechu L.) is a popular but carcinogenic chewing material used by approximately 200-600 million people worldwide. In the past few decades, AN has been discovered to possess genotoxic, cytostatic, and cytotoxic effects on cells. Some ingredients of AN, such as AN extract (ANE), arecoline, hydroxychavicol, and oligomeric procyanidins were demonstrated to stimulate apoptotic and/or growth arresting phenotypes in treated cells. However, our recent studies showed that ANE predominantly induces the autophagic responses, albeit the simultaneous initiation of apoptotic pathway. This finding may renew the knowledge about the cytotoxic effects of AN on oral cells in physiological conditions.

AB - Areca nut (AN, Areca catechu L.) is a popular but carcinogenic chewing material used by approximately 200-600 million people worldwide. In the past few decades, AN has been discovered to possess genotoxic, cytostatic, and cytotoxic effects on cells. Some ingredients of AN, such as AN extract (ANE), arecoline, hydroxychavicol, and oligomeric procyanidins were demonstrated to stimulate apoptotic and/or growth arresting phenotypes in treated cells. However, our recent studies showed that ANE predominantly induces the autophagic responses, albeit the simultaneous initiation of apoptotic pathway. This finding may renew the knowledge about the cytotoxic effects of AN on oral cells in physiological conditions.

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M3 - Chapter

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SN - 9781617619786

SP - 167

EP - 172

BT - Nuts: Properties, Consumption and Nutrition

PB - Nova Science Publishers Inc

ER -

Areca nut may kill cells in a different way

Abstract

ASJC Scopus subject areas

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