Areca nut may kill cells in a different way

Mei Huei Lin, Shyun Yeu Liu, Young Chau Liu

Research output: Chapter in Book/Report/Conference proceedingChapter


Areca nut (AN, Areca catechu L.) is a popular but carcinogenic chewing material used by approximately 200-600 million people worldwide. In the past few decades, AN has been discovered to possess genotoxic, cytostatic, and cytotoxic effects on cells. Some ingredients of AN, such as AN extract (ANE), arecoline, hydroxychavicol, and oligomeric procyanidins were demonstrated to stimulate apoptotic and/or growth arresting phenotypes in treated cells. However, our recent studies showed that ANE predominantly induces the autophagic responses, albeit the simultaneous initiation of apoptotic pathway. This finding may renew the knowledge about the cytotoxic effects of AN on oral cells in physiological conditions.

Original languageEnglish
Title of host publicationNuts: Properties, Consumption and Nutrition
Subtitle of host publicationProperties, Consumption and Nutrition
PublisherNova Science Publishers Inc
Number of pages6
ISBN (Print)9781617619786
Publication statusPublished - 2011

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences


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