Are Middle-Aged Men with Chronic Kidney Disease at Higher Risk of Having Nocturia than Age-Matched Controls

Chun Kai Hsu, Mei Yi Wu, I. Ni Chiang, Stephen S.D. Yang, Shang Jen Chang

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Objective: We compared the lower urinary tract symptoms between middle-aged men with and without chronic kidney disease (CKD) under 50 years of age. Methods: Between October 2010 and July 2013, patients with CKD aged below 50 who received regular follow-ups at the nephrology outpatient clinics were enrolled. We also enrolled men aged below 50 years with estimated glomerular filtration rates (eGFR) higher than 60 mL/min per 1.73 m2 and without history of kidney diseases from the health examination department as the control group. Clinical parameters and laboratory parameters were collected for analysis and comparison. The lower urinary tract symptoms were evaluated using the International Prostate Symptom Score (IPSS). Metabolic syndromes were defined according to the ATP III guidelines. Results: Overall, 50 men with CKD and 187 age-matched men without CKD were enrolled in the study (age: 44.9 ± 6.9 vs. 43.7.0 ± 4.3, P = 0.11). When compared with the age-matched control group, the occurrences of lower urinary tract symptoms were fewer in CKD patients, though not statistically significant. CKD Patients had significantly higher scores of nocturia (1.3 vs. 0.8, P = 0.02) but had significantly less urinary frequency and relatively fewer urgency score. Nocturia was significantly associated with eGFR. Multivariate analysis showed that lower eGFR and overweight were the only two independent risk factors for nocturia (P <0.01), but was not the case for metabolic syndromes. Conclusion: Middle-aged men with CKD had significantly more nocturia episodes than the age-matched control group, but had lower urinary frequency scores. Lower eGFR and overweight are independent risk factors for nocturia in middle-aged men.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalLUTS: Lower Urinary Tract Symptoms
Issue number3
Publication statusPublished - Sept 1 2015


  • Chronic kidney disease
  • Diabetes
  • Nocturia

ASJC Scopus subject areas

  • Neurology
  • Urology


Dive into the research topics of 'Are Middle-Aged Men with Chronic Kidney Disease at Higher Risk of Having Nocturia than Age-Matched Controls'. Together they form a unique fingerprint.

Cite this