TY - JOUR
T1 - Are intrinsic neural timescales related to sensory processing? Evidence from abnormal behavioral states
AU - Zilio, Federico
AU - Gomez-Pilar, Javier
AU - Cao, Shumei
AU - Zhang, Jun
AU - Zang, Di
AU - Qi, Zengxin
AU - Tan, Jiaxing
AU - Hiromi, Tanigawa
AU - Wu, Xuehai
AU - Fogel, Stuart
AU - Huang, Zirui
AU - Hohmann, Matthias R.
AU - Fomina, Tatiana
AU - Synofzik, Matthis
AU - Grosse-Wentrup, Moritz
AU - Owen, Adrian M.
AU - Northoff, Georg
N1 - Funding Information:
This work was supported by the grants from the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2), EJLB-Michael Smith Foundation, the Canadian Institutes of Health Research (CIHR), the Ministry of Science and Technology of China, the National Key R&D Program of China (2016YFC1306700), Canada Research Chair (CRC) program, the Start-up Research Grant in Hangzhou Normal University (to Georg Northoff), CIBER-BBN (ISCIII), co-funded with FEDER (Instituto de Salud Carlos III/FEDER) funds (to Javier Gomez-Pilar) and the Canada Excellence Research Chairs (CERC) program (to Adrian M. Owen).
Funding Information:
This work was supported by the grants from the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2), EJLB-Michael Smith Foundation, the Canadian Institutes of Health Research (CIHR), the Ministry of Science and Technology of China, the National Key R&D Program of China ( 2016YFC1306700 ), Canada Research Chair (CRC) program, the Start-up Research Grant in Hangzhou Normal University (to Georg Northoff), CIBER-BBN (ISCIII), co-funded with FEDER (Instituto de Salud Carlos III/FEDER) funds (to Javier Gomez-Pilar) and the Canada Excellence Research Chairs (CERC) program (to Adrian M. Owen).
Publisher Copyright:
© 2020
PY - 2021/2/1
Y1 - 2021/2/1
N2 - The brain exhibits a complex temporal structure which translates into a hierarchy of distinct neural timescales. An open question is how these intrinsic timescales are related to sensory or motor information processing and whether these dynamics have common patterns in different behavioral states. We address these questions by investigating the brain's intrinsic timescales in healthy controls, motor (amyotrophic lateral sclerosis, locked-in syndrome), sensory (anesthesia, unresponsive wakefulness syndrome), and progressive reduction of sensory processing (from awake states over N1, N2, N3). We employed a combination of measures from EEG resting-state data: auto-correlation window (ACW), power spectral density (PSD), and power-law exponent (PLE). Prolonged neural timescales accompanied by a shift towards slower frequencies were observed in the conditions with sensory deficits, but not in conditions with motor deficits. Our results establish that the spontaneous activity's intrinsic neural timescale is related to the neural capacity that specifically supports sensory rather than motor information processing in the healthy brain.
AB - The brain exhibits a complex temporal structure which translates into a hierarchy of distinct neural timescales. An open question is how these intrinsic timescales are related to sensory or motor information processing and whether these dynamics have common patterns in different behavioral states. We address these questions by investigating the brain's intrinsic timescales in healthy controls, motor (amyotrophic lateral sclerosis, locked-in syndrome), sensory (anesthesia, unresponsive wakefulness syndrome), and progressive reduction of sensory processing (from awake states over N1, N2, N3). We employed a combination of measures from EEG resting-state data: auto-correlation window (ACW), power spectral density (PSD), and power-law exponent (PLE). Prolonged neural timescales accompanied by a shift towards slower frequencies were observed in the conditions with sensory deficits, but not in conditions with motor deficits. Our results establish that the spontaneous activity's intrinsic neural timescale is related to the neural capacity that specifically supports sensory rather than motor information processing in the healthy brain.
KW - Amyotrophic lateral sclerosis
KW - Anesthesia
KW - Auto-correlation window
KW - Intrinsic neural timescales
KW - Unresponsive wakefulness syndrome
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U2 - 10.1016/j.neuroimage.2020.117579
DO - 10.1016/j.neuroimage.2020.117579
M3 - Article
C2 - 33221441
AN - SCOPUS:85096860469
SN - 1053-8119
VL - 226
JO - NeuroImage
JF - NeuroImage
M1 - 117579
ER -