Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: Detected by terminal-deoxynucleotidyl-transferase- mediated dUTP-FITC nick end labelling (TUNEL)

H. J. Harn; K. L. Shen; K. C. Yueh; L. I. Ho; J. C. Yu; S. C. Chiu; W. H. Lee

Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: Detected by terminal-deoxynucleotidyl-transferase- mediated dUTP-FITC nick end labelling (TUNEL)

H. J. Harn, K. L. Shen, K. C. Yueh, L. I. Ho, J. C. Yu, S. C. Chiu, W. H. Lee

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: We examined the relationship between apoptosis and three different major stages of human breast carcinoma: intraductal carcinoma (DCIS), infiltrating duct carcinoma (IDC) and metastatic carcinoma in lymph nodes. We also determined the correlation between apoptosis and oestrogen receptor (ER), progesterone receptor (PR) and p53. Methods and results: The study investigates the extent of apoptosis in 63 breast carcinomas by in-situ endlabelling, in formalin-fixed, paraffin-processed tissue sections. The 63 breast carcinomas, included 22 DCISs, 26 IDCs, three infiltrating lobular carcinomas (ILC) and 12 metastatic lymph nodes. The apoptotic labelling index was higher in DCIS than IDC and metastatic carcinoma (P

Original language	English
Pages (from-to)	534-539
Number of pages	6
Journal	Histopathology
Volume	31
Issue number	6
Publication status	Published - 1997
Externally published	Yes

Keywords

Apoptosis
Oestrogen receptor
p53
Progesterone receptor
TUNEL

ASJC Scopus subject areas

Anatomy
Pathology and Forensic Medicine
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Harn, H. J., Shen, K. L., Yueh, K. C., Ho, L. I., Yu, J. C., Chiu, S. C., & Lee, W. H. (1997). Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: Detected by terminal-deoxynucleotidyl-transferase- mediated dUTP-FITC nick end labelling (TUNEL). Histopathology, 31(6), 534-539.

Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: Detected by terminal-deoxynucleotidyl-transferase- mediated dUTP-FITC nick end labelling (TUNEL). / Harn, H. J.; Shen, K. L.; Yueh, K. C. et al.
In: Histopathology, Vol. 31, No. 6, 1997, p. 534-539.

Research output: Contribution to journal › Article › peer-review

Harn, HJ, Shen, KL, Yueh, KC, Ho, LI, Yu, JC, Chiu, SC & Lee, WH 1997, 'Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: Detected by terminal-deoxynucleotidyl-transferase- mediated dUTP-FITC nick end labelling (TUNEL)', Histopathology, vol. 31, no. 6, pp. 534-539.

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abstract = "Aims: We examined the relationship between apoptosis and three different major stages of human breast carcinoma: intraductal carcinoma (DCIS), infiltrating duct carcinoma (IDC) and metastatic carcinoma in lymph nodes. We also determined the correlation between apoptosis and oestrogen receptor (ER), progesterone receptor (PR) and p53. Methods and results: The study investigates the extent of apoptosis in 63 breast carcinomas by in-situ endlabelling, in formalin-fixed, paraffin-processed tissue sections. The 63 breast carcinomas, included 22 DCISs, 26 IDCs, three infiltrating lobular carcinomas (ILC) and 12 metastatic lymph nodes. The apoptotic labelling index was higher in DCIS than IDC and metastatic carcinoma (P",

keywords = "Apoptosis, Oestrogen receptor, p53, Progesterone receptor, TUNEL",

author = "Harn, {H. J.} and Shen, {K. L.} and Yueh, {K. C.} and Ho, {L. I.} and Yu, {J. C.} and Chiu, {S. C.} and Lee, {W. H.}",

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T1 - Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression

T2 - Detected by terminal-deoxynucleotidyl-transferase- mediated dUTP-FITC nick end labelling (TUNEL)

AU - Harn, H. J.

AU - Shen, K. L.

AU - Yueh, K. C.

AU - Ho, L. I.

AU - Yu, J. C.

AU - Chiu, S. C.

AU - Lee, W. H.

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Y1 - 1997

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AB - Aims: We examined the relationship between apoptosis and three different major stages of human breast carcinoma: intraductal carcinoma (DCIS), infiltrating duct carcinoma (IDC) and metastatic carcinoma in lymph nodes. We also determined the correlation between apoptosis and oestrogen receptor (ER), progesterone receptor (PR) and p53. Methods and results: The study investigates the extent of apoptosis in 63 breast carcinomas by in-situ endlabelling, in formalin-fixed, paraffin-processed tissue sections. The 63 breast carcinomas, included 22 DCISs, 26 IDCs, three infiltrating lobular carcinomas (ILC) and 12 metastatic lymph nodes. The apoptotic labelling index was higher in DCIS than IDC and metastatic carcinoma (P

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KW - Oestrogen receptor

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Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: Detected by terminal-deoxynucleotidyl-transferase- mediated dUTP-FITC nick end labelling (TUNEL)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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