Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage

H. J. Harn; H. F. Hsieh; L. I. Ho; C. P. Yu; J. H. Chen; C. C. Chiu; H. C. Fan; W. H. Lee

doi:10.1046/j.1365-2559.1998.00470.x

Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage

H. J. Harn, H. F. Hsieh, L. I. Ho, C. P. Yu, J. H. Chen, C. C. Chiu, H. C. Fan, W. H. Lee

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Aims: We investigated the significance of apoptosis, using the terminal deoxynucleotidyl transferase mediated dUTP-digoxigenin nick end-labelling method, in nasopharyngeal carcinoma biopsy samples. Methods and results: The apoptotic index (AI) in 50 nasopharyngeal carcinomas was compared with various histopathological features and clinical stage. Also, the AI was correlated with p53, bcl-2 and Ki67 expression by immunohistochemistry. In histopathological studies, the AI was significantly higher in mixed cellular type (MC) than in keratizing squamous cell type (KS) and spindle cell type (SC) (P

Original language	English
Pages (from-to)	117-122
Number of pages	6
Journal	Histopathology
Volume	33
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2559.1998.00470.x
Publication status	Published - 1998
Externally published	Yes

Keywords

Apoptosis
bcl-2
Ki67
Nasopharyngeal carcinoma
p53

ASJC Scopus subject areas

Anatomy
Pathology and Forensic Medicine
Cell Biology

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10.1046/j.1365-2559.1998.00470.x

Cite this

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title = "Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage",

abstract = "Aims: We investigated the significance of apoptosis, using the terminal deoxynucleotidyl transferase mediated dUTP-digoxigenin nick end-labelling method, in nasopharyngeal carcinoma biopsy samples. Methods and results: The apoptotic index (AI) in 50 nasopharyngeal carcinomas was compared with various histopathological features and clinical stage. Also, the AI was correlated with p53, bcl-2 and Ki67 expression by immunohistochemistry. In histopathological studies, the AI was significantly higher in mixed cellular type (MC) than in keratizing squamous cell type (KS) and spindle cell type (SC) (P",

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author = "Harn, {H. J.} and Hsieh, {H. F.} and Ho, {L. I.} and Yu, {C. P.} and Chen, {J. H.} and Chiu, {C. C.} and Fan, {H. C.} and Lee, {W. H.}",

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T1 - Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage

AU - Harn, H. J.

AU - Hsieh, H. F.

AU - Ho, L. I.

AU - Yu, C. P.

AU - Chen, J. H.

AU - Chiu, C. C.

AU - Fan, H. C.

AU - Lee, W. H.

PY - 1998

Y1 - 1998

N2 - Aims: We investigated the significance of apoptosis, using the terminal deoxynucleotidyl transferase mediated dUTP-digoxigenin nick end-labelling method, in nasopharyngeal carcinoma biopsy samples. Methods and results: The apoptotic index (AI) in 50 nasopharyngeal carcinomas was compared with various histopathological features and clinical stage. Also, the AI was correlated with p53, bcl-2 and Ki67 expression by immunohistochemistry. In histopathological studies, the AI was significantly higher in mixed cellular type (MC) than in keratizing squamous cell type (KS) and spindle cell type (SC) (P

AB - Aims: We investigated the significance of apoptosis, using the terminal deoxynucleotidyl transferase mediated dUTP-digoxigenin nick end-labelling method, in nasopharyngeal carcinoma biopsy samples. Methods and results: The apoptotic index (AI) in 50 nasopharyngeal carcinomas was compared with various histopathological features and clinical stage. Also, the AI was correlated with p53, bcl-2 and Ki67 expression by immunohistochemistry. In histopathological studies, the AI was significantly higher in mixed cellular type (MC) than in keratizing squamous cell type (KS) and spindle cell type (SC) (P

KW - Apoptosis

KW - bcl-2

KW - Ki67

KW - Nasopharyngeal carcinoma

KW - p53

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Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage

Abstract

Keywords

ASJC Scopus subject areas

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