Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Tien Huang Lin; Sunny Li Yun Chang; Pham Minh Khanh; Nguyen Thi Nha Trang; Shan Chi Liu; Hsiao Chi Tsai; An Chen Chang; Jo Yu Lin; Po Chun Chen; Ju Fang Liu; Jeng Hung Guo; Chun Lin Liu; Hsi Chin Wu; Chih Hsin Tang

doi:10.3390/cells11203285

Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Tien Huang Lin
, Sunny Li Yun Chang
, Pham Minh Khanh
, Nguyen Thi Nha Trang
, Shan Chi Liu
, Hsiao Chi Tsai
, An Chen Chang
, Jo Yu Lin
, Po Chun Chen
, Ju Fang Liu
, Jeng Hung Guo
, Chun Lin Liu
, Hsi Chin Wu
, Chih Hsin Tang

School of Oral Hygiene

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.

Original language	English
Article number	3285
Journal	Cells
Volume	11
Issue number	20
DOIs	https://doi.org/10.3390/cells11203285
Publication status	Published - Oct 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

apelin
metastasis
miR-106-5p
prostate cancer
TIMP2

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.3390/cells11203285

Cite this

@article{c478405da85348bfb315d2fc4bc2acf7,

title = "Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression",

abstract = "Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.",

keywords = "apelin, metastasis, miR-106-5p, prostate cancer, TIMP2",

author = "Lin, \{Tien Huang\} and Chang, \{Sunny Li Yun\} and Khanh, \{Pham Minh\} and Trang, \{Nguyen Thi Nha\} and Liu, \{Shan Chi\} and Tsai, \{Hsiao Chi\} and Chang, \{An Chen\} and Lin, \{Jo Yu\} and Chen, \{Po Chun\} and Liu, \{Ju Fang\} and Guo, \{Jeng Hung\} and Liu, \{Chun Lin\} and Wu, \{Hsi Chin\} and Tang, \{Chih Hsin\}",

note = "Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (MOST 110-2314-B-039-012, 111-2314-B-039-051, and 110-2341-B-341-001-MY2), China Medical University Beigang Hospital (CMUBHR 108-012, 110CMURBHR-07, and CMUBHR109-007), and China Medical University hospital (DMR-110-091; DMR-111-095; DMR-111-099). Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

doi = "10.3390/cells11203285",

language = "English",

volume = "11",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "20",

}

TY - JOUR

T1 - Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

AU - Lin, Tien Huang

AU - Chang, Sunny Li Yun

AU - Khanh, Pham Minh

AU - Trang, Nguyen Thi Nha

AU - Liu, Shan Chi

AU - Tsai, Hsiao Chi

AU - Chang, An Chen

AU - Lin, Jo Yu

AU - Chen, Po Chun

AU - Liu, Ju Fang

AU - Guo, Jeng Hung

AU - Liu, Chun Lin

AU - Wu, Hsi Chin

AU - Tang, Chih Hsin

N1 - Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (MOST 110-2314-B-039-012, 111-2314-B-039-051, and 110-2341-B-341-001-MY2), China Medical University Beigang Hospital (CMUBHR 108-012, 110CMURBHR-07, and CMUBHR109-007), and China Medical University hospital (DMR-110-091; DMR-111-095; DMR-111-099). Publisher Copyright: © 2022 by the authors.

PY - 2022/10

Y1 - 2022/10

N2 - Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.

AB - Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.

KW - apelin

KW - metastasis

KW - miR-106-5p

KW - prostate cancer

KW - TIMP2

UR - https://www.scopus.com/pages/publications/85140606221

UR - https://www.scopus.com/pages/publications/85140606221#tab=citedBy

U2 - 10.3390/cells11203285

DO - 10.3390/cells11203285

M3 - Article

C2 - 36291151

AN - SCOPUS:85140606221

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 20

M1 - 3285

ER -

Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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