APCcdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division

Alexandra Reis; Heng Yu Chang; Mark Levasseur; Keith T. Jones

doi:10.1038/ncb1406

APC^cdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division

Alexandra Reis, Heng Yu Chang, Mark Levasseur, Keith T. Jones

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Abstract

Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APC^cdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APC^cdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

Original language	English
Pages (from-to)	539-540
Number of pages	2
Journal	Nature Cell Biology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/ncb1406
Publication status	Published - May 2006
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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title = "APCcdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division",

abstract = "Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.",

author = "Alexandra Reis and Chang, {Heng Yu} and Mark Levasseur and Jones, {Keith T.}",

note = "Funding Information: The Wellcome Trust supported this work with a project grant (075744) and equipment grant (065354) to K.T.J. We thank M. Aitchison for the preparation of figures.",

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AU - Jones, Keith T.

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AB - Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

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APC^cdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division

Abstract

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