Antiviral activities of silymarin and derivatives

Ching Hsuan Liu, Alagie Jassey, Hsin Ya Hsu, Liang Tzung Lin

Research output: Contribution to journalReview articlepeer-review

59 Citations (Scopus)


Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.

Original languageEnglish
Article number1552
Issue number8
Publication statusPublished - Apr 19 2019


  • Antiviral
  • Drug development
  • Flavonolignans
  • Silymarin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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