Antitumor agents. Part 3: Synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives

Li Ming Yang; Shwu Jiuan Lin; Fen Lin Hsu; Tsang Hsiung Yang

doi:10.1016/S0960-894X(02)00092-6

Antitumor agents. Part 3: Synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives

Li Ming Yang, Shwu Jiuan Lin, Fen Lin Hsu, Tsang Hsiung Yang

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI₅₀=0.205 μM) and HT-29 colon cancer (GI₅₀=0.554 μM), respectively.

Original language	English
Pages (from-to)	1013-1015
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(02)00092-6
Publication status	Published - Apr 8 2002

ASJC Scopus subject areas

Drug Discovery
Molecular Medicine
Molecular Biology
Biochemistry
Clinical Biochemistry
Pharmaceutical Science
Organic Chemistry

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10.1016/S0960-894X(02)00092-6

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abstract = "A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI50=0.205 μM) and HT-29 colon cancer (GI50=0.554 μM), respectively.",

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AU - Lin, Shwu Jiuan

AU - Hsu, Fen Lin

AU - Yang, Tsang Hsiung

PY - 2002/4/8

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Antitumor agents. Part 3: Synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives

Abstract

ASJC Scopus subject areas

UN SDGs

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