Antitumor agents. 2. Synthesis and cytotoxic evaluation of 10- bromorutaecarpine

Li Ming Yang, Shwu Jiuan Lin, Lie Chwen Lin, Yao Haur Kuo

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Derivatives of the quinazolinocarboline alkaloid rutaecarpine, including 10-bromorutaecarpine (1), were synthesized and evaluated for cytotoxicity against several human tumor cell lines. The more potent derivative found in this study was compound 1, which exhibited significant activity against SF- 295 and ovarian cancer cell lines.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalChinese Pharmaceutical Journal
Issue number3
Publication statusPublished - Jun 1999


  • Antitumor
  • Evodia rutaecarpa
  • Quinazolinocarboline alkaloid
  • Rutaecarpine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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