Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia

Ching Chiung Wang, Lih Geeng Chen, Ling Ling Yang

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


We evaluated the antitumor activities of four macrocyclic hydrolyzable tannin dimers, cuphiin D1, cuphiin D2, oenothein B and woodfordin C isolated from Cuphea hyssopifolia (Lythraceae). All significantly inhibited the growth of the human carcinoma cell lines KB, HeLa, DU-145, Hep 3B, and the leukemia cell line HL-60, and showed less cytotoxicity than adriamycin against a normal cell line (WISH). All four compounds inhibited the viability of S-180 tumor cells in an in vitro assay and an in vivo S-180 tumor-bearing ICR mice model. Oenothein B demonstrated the greatest cytotoxicity (IC50=11.4 μg/ml) against S-180 tumor cells in culture, while cuphiin D1 resulted in the greatest increase in survival on S-180 tumor-bearing mice (%ILS=84.1%). Our findings suggest that the antitumor effects of these compounds are not only related to their cytotoxicity on carcinoma cell lines, but also depended on a host-mediated mechanism; they may therefore have potential for antitumor applications. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalCancer Letters
Issue number1-2
Publication statusPublished - Jun 1 1999


  • Antitumor activity in vivo and in vitro
  • Cuphiin D
  • Cuphiin D
  • Oenothein B
  • Woodfordin C

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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