TY - JOUR
T1 - Antipsychotic use is inversely associated with gastric cancer risk
T2 - A nationwide population-based nested case-control study
AU - Hsieh, Yi Hsuan
AU - Chan, Hsiang Lin
AU - Lin, Chiao Fan
AU - Liang, Sophie Hsin Yi
AU - Lu, Mong Liang
AU - McIntyre, Roger S.
AU - Lee, Yena
AU - Lin, Tzu Chin
AU - Chiu, Wei Che
AU - Chen, Vincent Chin Hung
N1 - © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - OBJECTIVE: The association between antipsychotic use and gastric cancer risk remains unclear. Therefore, this study aimed to determine the association between antipsychotic exposure and the incidence of gastric cancer. METHODS: Using a nested case-control design, a total of 34 470 gastric cancer patients and 163 430 nongastric cancer controls were identified from Taiwan's National Health Insurance Research Database between 1 January 1997 and 31 December 2013. We analyzed the data using a conditional logistic regression model to adjust for possible confounding variables. RESULTS: Antipsychotic use was independently inversely associated with gastric cancer risk after controlling for potential confounding factors including income, urbanization, medications, physical and medical illness, aspirin use, nonsteroidal anti-inflammatory drug use and triple therapy. In addition, dose-dependent trends against gastric cancer risk were also shown with individual antipsychotic compounds including thioridazine, haloperidol, sulpiride, clozapine, olanzapine, quetiapine, amisulpride, and risperidone. A sensitivity analysis showed that second-generation antipsychotics had significant dose-dependent effects in reducing the risk of gastric cancer risk in patients with and without peptic ulcer disease. CONCLUSIONS: Antipsychotic use was inversely associated with gastric cancer risk, and dose-dependent effects against gastric cancer were also seen with several individual antipsychotic compounds.
AB - OBJECTIVE: The association between antipsychotic use and gastric cancer risk remains unclear. Therefore, this study aimed to determine the association between antipsychotic exposure and the incidence of gastric cancer. METHODS: Using a nested case-control design, a total of 34 470 gastric cancer patients and 163 430 nongastric cancer controls were identified from Taiwan's National Health Insurance Research Database between 1 January 1997 and 31 December 2013. We analyzed the data using a conditional logistic regression model to adjust for possible confounding variables. RESULTS: Antipsychotic use was independently inversely associated with gastric cancer risk after controlling for potential confounding factors including income, urbanization, medications, physical and medical illness, aspirin use, nonsteroidal anti-inflammatory drug use and triple therapy. In addition, dose-dependent trends against gastric cancer risk were also shown with individual antipsychotic compounds including thioridazine, haloperidol, sulpiride, clozapine, olanzapine, quetiapine, amisulpride, and risperidone. A sensitivity analysis showed that second-generation antipsychotics had significant dose-dependent effects in reducing the risk of gastric cancer risk in patients with and without peptic ulcer disease. CONCLUSIONS: Antipsychotic use was inversely associated with gastric cancer risk, and dose-dependent effects against gastric cancer were also seen with several individual antipsychotic compounds.
KW - cancer risk factors
KW - clinical cancer research
KW - digestive cancer
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U2 - 10.1002/cam4.2329
DO - 10.1002/cam4.2329
M3 - Article
C2 - 31183993
AN - SCOPUS:85071059146
SN - 2045-7634
VL - 8
SP - 4484
EP - 4496
JO - Cancer Medicine
JF - Cancer Medicine
IS - 9
ER -
