Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Ching Yu Yen; Chien Chih Chiu; Rou Wen Haung; Chi Chen Yeh; Kuang Jing Huang; Kuo Feng Chang; You Cheng Hseu; Fang Rong Chang; Hsueh Wei Chang; Yang Chang Wu

doi:10.1016/j.mrgentox.2012.06.003

Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Ching Yu Yen, Chien Chih Chiu, Rou Wen Haung, Chi Chen Yeh, Kuang Jing Huang, Kuo Feng Chang, You Cheng Hseu, Fang Rong Chang, Hsueh Wei Chang, Yang Chang Wu

School of Dentistry

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

Original language	English
Pages (from-to)	253-258
Number of pages	6
Journal	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume	747
Issue number	2
DOIs	https://doi.org/10.1016/j.mrgentox.2012.06.003
Publication status	Published - Sept 18 2012

Keywords

Apoptosis
Goniothalamin
Mitochondrial membrane potential
Oral cancer
ROS
γH2AX

ASJC Scopus subject areas

Genetics
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mrgentox.2012.06.003

Cite this

Yen, C. Y., Chiu, C. C., Haung, R. W., Yeh, C. C., Huang, K. J., Chang, K. F., Hseu, Y. C., Chang, F. R., Chang, H. W., & Wu, Y. C. (2012). Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 747(2), 253-258. https://doi.org/10.1016/j.mrgentox.2012.06.003

Yen, CY, Chiu, CC, Haung, RW, Yeh, CC, Huang, KJ, Chang, KF, Hseu, YC, Chang, FR, Chang, HW & Wu, YC 2012, 'Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction', Mutation Research - Genetic Toxicology and Environmental Mutagenesis, vol. 747, no. 2, pp. 253-258. https://doi.org/10.1016/j.mrgentox.2012.06.003

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abstract = "Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p",

keywords = "Apoptosis, Goniothalamin, Mitochondrial membrane potential, Oral cancer, ROS, γH2AX",

author = "Yen, {Ching Yu} and Chiu, {Chien Chih} and Haung, {Rou Wen} and Yeh, {Chi Chen} and Huang, {Kuang Jing} and Chang, {Kuo Feng} and Hseu, {You Cheng} and Chang, {Fang Rong} and Chang, {Hsueh Wei} and Wu, {Yang Chang}",

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doi = "10.1016/j.mrgentox.2012.06.003",

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AU - Yen, Ching Yu

AU - Chiu, Chien Chih

AU - Haung, Rou Wen

AU - Yeh, Chi Chen

AU - Huang, Kuang Jing

AU - Chang, Kuo Feng

AU - Hseu, You Cheng

AU - Chang, Fang Rong

AU - Chang, Hsueh Wei

AU - Wu, Yang Chang

PY - 2012/9/18

Y1 - 2012/9/18

N2 - Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

AB - Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

KW - Apoptosis

KW - Goniothalamin

KW - Mitochondrial membrane potential

KW - Oral cancer

KW - ROS

KW - γH2AX

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Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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