Antioxidative effects of tetramethylpyrazine on acute ethanol-induced lipid peroxidation

Chi Feng Liu, Chia Hsien Lin, Chin F. Chen, Tian Chyuan Huang, Song Chow Lin

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Acute p.o. administration of 99.5% ethanol (0.1 ml) to fasted mice produced heart toxicity. Pretreatment with p.o. administration of tetramethylpyrazine (TMP) could prevent such toxicity effectively and dose-dependently. The maximal antioxidative effect against 99.5% ethanol-induced heart toxicity could be observed at 1 hour after TMP administration. In order to further investigate the heart protective mechanism of TMP, both lipid peroxidation level in vivo and superoxide scavenging activity were conducted. TMP exhibited a dose-dependently anti-lipid peroxidation effect in mice heart homogenate, and results indicated that 99.5% ethanol-induced intoxicated mice hearts have higher malonic dialdehyde (MDA) levels compared with those in TMP administrated mice hearts. These results suggest that the potentially heart protective mechanism of TMP could be contributed, at least in part, to its prominent anti-lipid peroxidation and anti-free radical formation effects, hence it could protect the heart from lipid peroxidation-induced heart toxicity.

Original languageEnglish
Pages (from-to)981-988
Number of pages8
JournalAmerican Journal of Chinese Medicine
Issue number6
Publication statusPublished - 2005


  • Antioxidative
  • Ethanol
  • Lipid peroxidation
  • Tetramethylpyrazine

ASJC Scopus subject areas

  • Complementary and alternative medicine


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