TY - JOUR
T1 - Antioxidant and heme oxygenase-1 (HO-1)-induced effects of selected Taiwanese plants
AU - Lee, Mei Hsien
AU - Jiang, Cheun Bin
AU - Juan, Shu Hui
AU - Lin, Rong Dih
AU - Hou, Wen Chi
PY - 2006/2
Y1 - 2006/2
N2 - Recent studies have shown biological effects of heme oxygenase-1 (HO-1) induction and antioxidation in cardiovascular disorders. The ethanol extracts of leaves of 12 selected indigenous Taiwanese plants were investigated for their antioxidant activities, evaluated using assays of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl, and superoxide radicals scavenging and reducing power activities as well as the induction of heme oxygenase-1 (HO-1). Acer albopurpurascens, Cinnamomum kanehirai, Diospyros discolor, Excoecaria kawakamii, Koelreuteria henryi, and Syzygium formosanum showed better DPPH-scavenging activities than the other plants. IC50 values ranged from 1.7 to 8.7 μg/mL. Excepting Millettia pulchra var. microphylla and Pittosporum moluccanum, the extracts displayed hydroxyl-scavenging activities (IC50 of 0.16-0.67 μg/mL). A. albopurpurascens, D. discolor, K. henryi, and S. formosanum also showed good superoxide anion radical scavenging activities and IC50 values ranged from 12.9 to 28.5 μg/mL. D. discolor, K. henryi, and S. formosanum showed potent reducing power and M. pulchra var. microphylla and S. formosanum exhibited potent HO-1 induced activity. These active plant extracts also contained abundant phenolic constituents. The present results provide candidates to isolate the active constituents and develop natural antioxidants.
AB - Recent studies have shown biological effects of heme oxygenase-1 (HO-1) induction and antioxidation in cardiovascular disorders. The ethanol extracts of leaves of 12 selected indigenous Taiwanese plants were investigated for their antioxidant activities, evaluated using assays of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl, and superoxide radicals scavenging and reducing power activities as well as the induction of heme oxygenase-1 (HO-1). Acer albopurpurascens, Cinnamomum kanehirai, Diospyros discolor, Excoecaria kawakamii, Koelreuteria henryi, and Syzygium formosanum showed better DPPH-scavenging activities than the other plants. IC50 values ranged from 1.7 to 8.7 μg/mL. Excepting Millettia pulchra var. microphylla and Pittosporum moluccanum, the extracts displayed hydroxyl-scavenging activities (IC50 of 0.16-0.67 μg/mL). A. albopurpurascens, D. discolor, K. henryi, and S. formosanum also showed good superoxide anion radical scavenging activities and IC50 values ranged from 12.9 to 28.5 μg/mL. D. discolor, K. henryi, and S. formosanum showed potent reducing power and M. pulchra var. microphylla and S. formosanum exhibited potent HO-1 induced activity. These active plant extracts also contained abundant phenolic constituents. The present results provide candidates to isolate the active constituents and develop natural antioxidants.
KW - Heme oxygenase-1
KW - Indigenous Taiwanese plants
KW - Reducing power
KW - Superoxide
UR - http://www.scopus.com/inward/record.url?scp=32344437223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=32344437223&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2005.11.012
DO - 10.1016/j.fitote.2005.11.012
M3 - Article
C2 - 16403605
AN - SCOPUS:32344437223
SN - 0367-326X
VL - 77
SP - 109
EP - 115
JO - Fitoterapia
JF - Fitoterapia
IS - 2
ER -