Antioxidant and anti-inflammatory properties of taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds

Chuan Sung Chiu; Jeng Shyan Deng; Heng Yuan Chang; Yi Chuan Chen; Min Min Lee; Wen Chi Hou; Chao Ying Lee; Shyh Shyun Huang; Guan Jhong Huang

doi:10.1016/j.foodchem.2013.04.031

Antioxidant and anti-inflammatory properties of taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds

Chuan Sung Chiu, Jeng Shyan Deng, Heng Yuan Chang, Yi Chuan Chen, Min Min Lee, Wen Chi Hou, Chao Ying Lee, Shyh Shyun Huang, Guan Jhong Huang

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Dioscorea japonica Thunb. var. pseudojaponica (DP) is consumed as food and widely used in traditional Chinese medicine in Taiwan. The aims of this study are to investigate the antioxidant and anti-inflammatory effects of ethanol extract of DP (EDP) and its reference compounds. Fingerprint chromatogram from HPLC indicated that EDP contains gallic acid and vanillic acid. EDP was evaluated for its antioxidant effects and LPS-induced nitrite oxide (NO) production in RAW264.7 cells. EDP decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells. In-vivo anti-inflammatory activities of EDP were assessed in mouse paw oedema induced by λ-carrageenan (Carr). We investigated the antioxidant mechanism of EDP via studies of the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and the levels of malondialdehyde (MDA) in the oedematous paw. The results showed that EDP might be a natural antioxidant and anti-inflammatory agent.

Original language	English
Pages (from-to)	1087-1096
Number of pages	10
Journal	Food Chemistry
Volume	141
Issue number	2
DOIs	https://doi.org/10.1016/j.foodchem.2013.04.031
Publication status	Published - 2013

Keywords

Anti-inflammation
Antioxidant
Dioscorea japonica Thunb. var.
Pseudojaponica
Taiwanese yam

ASJC Scopus subject areas

Analytical Chemistry
Food Science

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10.1016/j.foodchem.2013.04.031

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title = "Antioxidant and anti-inflammatory properties of taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds",

abstract = "Dioscorea japonica Thunb. var. pseudojaponica (DP) is consumed as food and widely used in traditional Chinese medicine in Taiwan. The aims of this study are to investigate the antioxidant and anti-inflammatory effects of ethanol extract of DP (EDP) and its reference compounds. Fingerprint chromatogram from HPLC indicated that EDP contains gallic acid and vanillic acid. EDP was evaluated for its antioxidant effects and LPS-induced nitrite oxide (NO) production in RAW264.7 cells. EDP decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells. In-vivo anti-inflammatory activities of EDP were assessed in mouse paw oedema induced by λ-carrageenan (Carr). We investigated the antioxidant mechanism of EDP via studies of the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and the levels of malondialdehyde (MDA) in the oedematous paw. The results showed that EDP might be a natural antioxidant and anti-inflammatory agent.",

keywords = "Anti-inflammation, Antioxidant, Dioscorea japonica Thunb. var., Pseudojaponica, Taiwanese yam",

author = "Chiu, {Chuan Sung} and Deng, {Jeng Shyan} and Chang, {Heng Yuan} and Chen, {Yi Chuan} and Lee, {Min Min} and Hou, {Wen Chi} and Lee, {Chao Ying} and Huang, {Shyh Shyun} and Huang, {Guan Jhong}",

year = "2013",

doi = "10.1016/j.foodchem.2013.04.031",

language = "English",

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pages = "1087--1096",

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T1 - Antioxidant and anti-inflammatory properties of taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds

AU - Chiu, Chuan Sung

AU - Deng, Jeng Shyan

AU - Chang, Heng Yuan

AU - Chen, Yi Chuan

AU - Lee, Min Min

AU - Hou, Wen Chi

AU - Lee, Chao Ying

AU - Huang, Shyh Shyun

AU - Huang, Guan Jhong

PY - 2013

Y1 - 2013

N2 - Dioscorea japonica Thunb. var. pseudojaponica (DP) is consumed as food and widely used in traditional Chinese medicine in Taiwan. The aims of this study are to investigate the antioxidant and anti-inflammatory effects of ethanol extract of DP (EDP) and its reference compounds. Fingerprint chromatogram from HPLC indicated that EDP contains gallic acid and vanillic acid. EDP was evaluated for its antioxidant effects and LPS-induced nitrite oxide (NO) production in RAW264.7 cells. EDP decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells. In-vivo anti-inflammatory activities of EDP were assessed in mouse paw oedema induced by λ-carrageenan (Carr). We investigated the antioxidant mechanism of EDP via studies of the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and the levels of malondialdehyde (MDA) in the oedematous paw. The results showed that EDP might be a natural antioxidant and anti-inflammatory agent.

AB - Dioscorea japonica Thunb. var. pseudojaponica (DP) is consumed as food and widely used in traditional Chinese medicine in Taiwan. The aims of this study are to investigate the antioxidant and anti-inflammatory effects of ethanol extract of DP (EDP) and its reference compounds. Fingerprint chromatogram from HPLC indicated that EDP contains gallic acid and vanillic acid. EDP was evaluated for its antioxidant effects and LPS-induced nitrite oxide (NO) production in RAW264.7 cells. EDP decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells. In-vivo anti-inflammatory activities of EDP were assessed in mouse paw oedema induced by λ-carrageenan (Carr). We investigated the antioxidant mechanism of EDP via studies of the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and the levels of malondialdehyde (MDA) in the oedematous paw. The results showed that EDP might be a natural antioxidant and anti-inflammatory agent.

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KW - Antioxidant

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KW - Pseudojaponica

KW - Taiwanese yam

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Antioxidant and anti-inflammatory properties of taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds

Abstract

Keywords

ASJC Scopus subject areas

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