Antioxidant and amine oxidase inhibitory activities of hydroxyurea

Yuh Hwa Liu; Wen Chun Wu; Yeh Lin Lu; Ying Jang Lai; Wen Chi Hou

doi:10.1271/bbb.100096

Antioxidant and amine oxidase inhibitory activities of hydroxyurea

Yuh Hwa Liu, Wen Chun Wu, Yeh Lin Lu, Ying Jang Lai, Wen Chi Hou

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Hydroxyurea (HU, NH₂CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.

Original language	English
Pages (from-to)	1256-1260
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	6
DOIs	https://doi.org/10.1271/bbb.100096
Publication status	Published - 2010

Keywords

Antioxidant activity
Hydroxyurea (HU)
Monoamine oxidase (MAO)
Semicarbaitive amine oxidase (SSAO)

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Analytical Chemistry
Molecular Biology
Biochemistry
Biotechnology
Organic Chemistry

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10.1271/bbb.100096

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title = "Antioxidant and amine oxidase inhibitory activities of hydroxyurea",

abstract = "Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.",

keywords = "Antioxidant activity, Hydroxyurea (HU), Monoamine oxidase (MAO), Semicarbaitive amine oxidase (SSAO)",

author = "Liu, {Yuh Hwa} and Wu, {Wen Chun} and Lu, {Yeh Lin} and Lai, {Ying Jang} and Hou, {Wen Chi}",

year = "2010",

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T1 - Antioxidant and amine oxidase inhibitory activities of hydroxyurea

AU - Liu, Yuh Hwa

AU - Wu, Wen Chun

AU - Lu, Yeh Lin

AU - Lai, Ying Jang

AU - Hou, Wen Chi

PY - 2010

Y1 - 2010

N2 - Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.

AB - Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.

KW - Antioxidant activity

KW - Hydroxyurea (HU)

KW - Monoamine oxidase (MAO)

KW - Semicarbaitive amine oxidase (SSAO)

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SN - 0916-8451

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 6

ER -

Antioxidant and amine oxidase inhibitory activities of hydroxyurea

Abstract

Keywords

ASJC Scopus subject areas

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