Abstract
Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.
Original language | English |
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Pages (from-to) | 1256-1260 |
Number of pages | 5 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 74 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- Antioxidant activity
- Hydroxyurea (HU)
- Monoamine oxidase (MAO)
- Semicarbaitive amine oxidase (SSAO)
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Analytical Chemistry
- Molecular Biology
- Biochemistry
- Biotechnology
- Organic Chemistry