Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Chi Han Wu; Chun Hsu Pan; Ching Kuo Lee; Ming Jyh Sheu; Fon Chang Liu; Guei Jane Wang; Chieh Hsi Wu

doi:10.1016/j.jff.2016.04.004

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Chi Han Wu, Chun Hsu Pan, Ching Kuo Lee, Ming Jyh Sheu, Fon Chang Liu, Guei Jane Wang, Chieh Hsi Wu

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement that promotes good health, is entirely composed of natural foods. Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. Experimental results showed that YSY reduced body weight, hyperlipidaemia, fatty liver, and atherogenesis in hyperlipidaemic mice. In addition, YSY promoted lipid metabolism by inducing adiponectin secretion and activation (phosphorylation) of 5' adenosine monophosphate-activated protein kinase (AMPK) and by suppressing the activation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR). Moreover, YSY inhibited adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPs). Furthermore, the antihyperlipidaemic effect of YSY was observed in the clinical trial. Our findings suggest that YSY is an adjuvant intervention for treating and preventing hyperlipidaemia, atherogenesis, and obesity.

Original language	English
Pages (from-to)	173-182
Number of pages	10
Journal	Journal of Functional Foods
Volume	24
DOIs	https://doi.org/10.1016/j.jff.2016.04.004
Publication status	Published - Jun 1 2016

Keywords

Adipocyte differentiation
Atherogenesis
Hyperlipidaemia
Obesity
Yan-Sheng-Yin

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jff.2016.04.004

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title = "Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans",

abstract = "Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement that promotes good health, is entirely composed of natural foods. Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. Experimental results showed that YSY reduced body weight, hyperlipidaemia, fatty liver, and atherogenesis in hyperlipidaemic mice. In addition, YSY promoted lipid metabolism by inducing adiponectin secretion and activation (phosphorylation) of 5' adenosine monophosphate-activated protein kinase (AMPK) and by suppressing the activation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR). Moreover, YSY inhibited adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPs). Furthermore, the antihyperlipidaemic effect of YSY was observed in the clinical trial. Our findings suggest that YSY is an adjuvant intervention for treating and preventing hyperlipidaemia, atherogenesis, and obesity.",

keywords = "Adipocyte differentiation, Atherogenesis, Hyperlipidaemia, Obesity, Yan-Sheng-Yin",

author = "Wu, {Chi Han} and Pan, {Chun Hsu} and Lee, {Ching Kuo} and Sheu, {Ming Jyh} and Liu, {Fon Chang} and Wang, {Guei Jane} and Wu, {Chieh Hsi}",

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year = "2016",

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doi = "10.1016/j.jff.2016.04.004",

language = "English",

volume = "24",

pages = "173--182",

journal = "Journal of Functional Foods",

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T1 - Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

AU - Wu, Chi Han

AU - Pan, Chun Hsu

AU - Lee, Ching Kuo

AU - Sheu, Ming Jyh

AU - Liu, Fon Chang

AU - Wang, Guei Jane

AU - Wu, Chieh Hsi

PY - 2016/6/1

Y1 - 2016/6/1

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AB - Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement that promotes good health, is entirely composed of natural foods. Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. Experimental results showed that YSY reduced body weight, hyperlipidaemia, fatty liver, and atherogenesis in hyperlipidaemic mice. In addition, YSY promoted lipid metabolism by inducing adiponectin secretion and activation (phosphorylation) of 5' adenosine monophosphate-activated protein kinase (AMPK) and by suppressing the activation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR). Moreover, YSY inhibited adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPs). Furthermore, the antihyperlipidaemic effect of YSY was observed in the clinical trial. Our findings suggest that YSY is an adjuvant intervention for treating and preventing hyperlipidaemia, atherogenesis, and obesity.

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ER -

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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