TY - JOUR
T1 - Antinucleosome antibodies correlate with the disease severity in children with systemic lupus erythematosus
AU - Wu, Ju Fang
AU - Yang, Yao Hsu
AU - Wang, Li Chieh
AU - Lee, Jyh Hong
AU - Shen, Ein Yiao
AU - Chiang, Bor Luen
N1 - Funding Information:
This study was supported by a grant from the National Science Council of the Republic of China.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/9
Y1 - 2006/9
N2 - We compared the serum levels of antinucleosome antibodies (anti-NCS Abs) in thirty pediatric systemic lupus erythematosus (SLE) patients by using enzyme-linked immunosorbent assay (ELISA) to 29 adult SLE patients, 30 healthy controls, 21 juvenile idiopathic arthritis (JIA) and 23 Henoch-Schonlein purpura (HSP) patients as autoimmune disease controls. The mean anti-NCS Ab titer in the pediatric SLE patients was 1552.7 ± 1842.2 U/ml, higher than those of adult SLE patients (194.3 ± 402.7 U/ml), normal controls (9.5 ± 5.7 U/ml) and disease controls (JIA: 7.7 ± 4.0 U/ml, HSP: 5.7 ± 4.4 U/ml) (p <0.05). The prevalence of both anti-NCS Ab (90%) and anti-ds DNA Ab (76.7%) in pediatric SLE patients were higher (p <0.05) than that of adult SLE patients (58.6% and 48.3%). A positive correlation was demonstrated between anti-NCS Ab and anti-dsDNA Ab as well as the SLEDAI scores in pediatric and adult patients (p <0.05). The inverse correlation of anti-NCS Ab levels with C3 was observed in both pediatric and adult SLE patients (pediatrics, r = - 0.61, p = 0.0003; adult, r = - 0.44, p = 0.02). Our data suggested that in pediatric SLE patients, anti-NCS Ab could be as good a marker for SLE diagnosis and disease activity assessment as in adult SLE patients.
AB - We compared the serum levels of antinucleosome antibodies (anti-NCS Abs) in thirty pediatric systemic lupus erythematosus (SLE) patients by using enzyme-linked immunosorbent assay (ELISA) to 29 adult SLE patients, 30 healthy controls, 21 juvenile idiopathic arthritis (JIA) and 23 Henoch-Schonlein purpura (HSP) patients as autoimmune disease controls. The mean anti-NCS Ab titer in the pediatric SLE patients was 1552.7 ± 1842.2 U/ml, higher than those of adult SLE patients (194.3 ± 402.7 U/ml), normal controls (9.5 ± 5.7 U/ml) and disease controls (JIA: 7.7 ± 4.0 U/ml, HSP: 5.7 ± 4.4 U/ml) (p <0.05). The prevalence of both anti-NCS Ab (90%) and anti-ds DNA Ab (76.7%) in pediatric SLE patients were higher (p <0.05) than that of adult SLE patients (58.6% and 48.3%). A positive correlation was demonstrated between anti-NCS Ab and anti-dsDNA Ab as well as the SLEDAI scores in pediatric and adult patients (p <0.05). The inverse correlation of anti-NCS Ab levels with C3 was observed in both pediatric and adult SLE patients (pediatrics, r = - 0.61, p = 0.0003; adult, r = - 0.44, p = 0.02). Our data suggested that in pediatric SLE patients, anti-NCS Ab could be as good a marker for SLE diagnosis and disease activity assessment as in adult SLE patients.
KW - Anti-double stranded DNA antibodies
KW - Antinucleosome antibodies
KW - Systemic lupus erythematosus
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U2 - 10.1016/j.jaut.2006.07.001
DO - 10.1016/j.jaut.2006.07.001
M3 - Article
C2 - 16919912
AN - SCOPUS:33749509704
SN - 0896-8411
VL - 27
SP - 119
EP - 124
JO - Journal of Autoimmunity
JF - Journal of Autoimmunity
IS - 2
ER -