Antimicrobial Gold Nanoclusters: Recent Developments and Future Perspectives

Sibidou Yougbare, Ting Kuang Chang, Shih Hua Tan, Jui Chi Kuo, Po Hsuan Hsu, Chen Yen Su, Tsung Rong Kuo

Research output: Contribution to journalReview articlepeer-review

101 Citations (Scopus)


Bacterial infections have caused serious threats to public health due to the antimicrobial resistance in bacteria. Recently, gold nanoclusters (AuNCs) have been extensively investigated for biomedical applications because of their superior structural and optical properties. Great efforts have demonstrated that AuNCs conjugated with various surface ligands are promising antimicrobial agents owing to their high biocompatibility, polyvalent effect, easy modification and photothermal stability. In this review, we have highlighted the recent achievements for the utilizations of AuNCs as the antimicrobial agents. We have classified the antimicrobial AuNCs by their surface ligands including small molecules (< 900 Daltons) and macromolecules (> 900 Daltons). Moreover, the antimicrobial activities and mechanisms of AuNCs have been introduced into two main categories of small molecules and macromolecules, respectively. In accordance with the advancements of antimicrobial AuNCs, we further provided conclusions of current challenges and recommendations of future perspectives of antimicrobial AuNCs for fundamental researches and clinical applications.

Original languageEnglish
Article number2924
JournalInternational Journal of Molecular Sciences
Issue number12
Publication statusPublished - Jun 14 2019


  • antimicrobial agent
  • antimicrobial mechanism
  • gold nanoclusters
  • macromolecule
  • small molecule

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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