Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme

Ju Chi Liu; Feng-Lin Hsu; Jen Chen Tsai; Paul Chan; Jenny Ya Hsin Liu; G. Neil Thomas; Brian Tomlinson; Ming Yu Lo; Jung Yaw Lin

doi:10.1016/S0024-3205(03)00481-8

Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme

Ju Chi Liu, Feng-Lin Hsu, Jen Chen Tsai, Paul Chan, Jenny Ya Hsin Liu, G. Neil Thomas, Brian Tomlinson, Ming Yu Lo, Jung Yaw Lin

Research output: Contribution to journal › Article › peer-review

129 Citations (Scopus)

Abstract

The tannins are natural polyphenols, able to precipitate water-soluble alkaloids and possess an inhibitory action on the angiotensin converting enzyme (ACE). We identified 18 polyphenolic compounds (tannins) from Chinese herbs and examined the in vitro effects of these tannins on ACE activity, including determination of the 50% inhibitory concentrations (IC ₅₀), specificity and mode of inhibition. We also assessed the in vivo inhibitory effect of the tannins on angiotensin I-induced blood pressure elevation in spontaneously hypertensive rats (SHR). Nine tannins with an IC ₅₀

Original language	English
Pages (from-to)	1543-1555
Number of pages	13
Journal	Life Sciences
Volume	73
Issue number	12
DOIs	https://doi.org/10.1016/S0024-3205(03)00481-8
Publication status	Published - Aug 8 2003

Keywords

Angiotensin converting enzyme
Inhibitor
Tannins
Traditional Chinese herbs

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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10.1016/S0024-3205(03)00481-8

Cite this

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title = "Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme",

abstract = "The tannins are natural polyphenols, able to precipitate water-soluble alkaloids and possess an inhibitory action on the angiotensin converting enzyme (ACE). We identified 18 polyphenolic compounds (tannins) from Chinese herbs and examined the in vitro effects of these tannins on ACE activity, including determination of the 50% inhibitory concentrations (IC 50), specificity and mode of inhibition. We also assessed the in vivo inhibitory effect of the tannins on angiotensin I-induced blood pressure elevation in spontaneously hypertensive rats (SHR). Nine tannins with an IC 50 ",

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T1 - Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme

AU - Liu, Ju Chi

AU - Hsu, Feng-Lin

AU - Tsai, Jen Chen

AU - Chan, Paul

AU - Liu, Jenny Ya Hsin

AU - Thomas, G. Neil

AU - Tomlinson, Brian

AU - Lo, Ming Yu

AU - Lin, Jung Yaw

PY - 2003/8/8

Y1 - 2003/8/8

N2 - The tannins are natural polyphenols, able to precipitate water-soluble alkaloids and possess an inhibitory action on the angiotensin converting enzyme (ACE). We identified 18 polyphenolic compounds (tannins) from Chinese herbs and examined the in vitro effects of these tannins on ACE activity, including determination of the 50% inhibitory concentrations (IC 50), specificity and mode of inhibition. We also assessed the in vivo inhibitory effect of the tannins on angiotensin I-induced blood pressure elevation in spontaneously hypertensive rats (SHR). Nine tannins with an IC 50

AB - The tannins are natural polyphenols, able to precipitate water-soluble alkaloids and possess an inhibitory action on the angiotensin converting enzyme (ACE). We identified 18 polyphenolic compounds (tannins) from Chinese herbs and examined the in vitro effects of these tannins on ACE activity, including determination of the 50% inhibitory concentrations (IC 50), specificity and mode of inhibition. We also assessed the in vivo inhibitory effect of the tannins on angiotensin I-induced blood pressure elevation in spontaneously hypertensive rats (SHR). Nine tannins with an IC 50

KW - Angiotensin converting enzyme

KW - Inhibitor

KW - Tannins

KW - Traditional Chinese herbs

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Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme

Abstract

Keywords

ASJC Scopus subject areas

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