Antihypertensive Activity of dl-Tetrahydropalmatine, an Active Alkaloid Isolated from the Tubers of Corydalis racemosa

Lian Hwa Chu; Feng Lin Hsu; Fu Yu Chueh; Chiang Shan Niu; Juei Tang Cheng

doi:10.1002/jccs.199600071

Antihypertensive Activity of dl-Tetrahydropalmatine, an Active Alkaloid Isolated from the Tubers of Corydalis racemosa

Lian Hwa Chu, Feng Lin Hsu, Fu Yu Chueh, Chiang Shan Niu, Juei Tang Cheng

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The antihypertensive activity of dl-tetrahydropalmatine hydrochloride (THP), isolated from the tubers of Corydalis racemosa (Thunb.) Pers. (Papaveraceae), was investigated in spontaneously hypertensive rats (SHRs) using intravenous injection. A dose-dependent lowering of blood pressure was observed in SHRs. Decrease of plasma noradrenaline was also obtained in SHRs that received injection of THP. Direct injection of THP into brain lowered the blood pressure and plasma noradrenaline. This antihypertensive action of THP appears to be produced mainly by an effect on central nervous system to lower sympathetic tone in SHRs.

Original language	English
Pages (from-to)	489-492
Number of pages	4
Journal	Journal of the Chinese Chemical Society
Volume	43
Issue number	6
DOIs	https://doi.org/10.1002/jccs.199600071
Publication status	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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title = "Antihypertensive Activity of dl-Tetrahydropalmatine, an Active Alkaloid Isolated from the Tubers of Corydalis racemosa",

abstract = "The antihypertensive activity of dl-tetrahydropalmatine hydrochloride (THP), isolated from the tubers of Corydalis racemosa (Thunb.) Pers. (Papaveraceae), was investigated in spontaneously hypertensive rats (SHRs) using intravenous injection. A dose-dependent lowering of blood pressure was observed in SHRs. Decrease of plasma noradrenaline was also obtained in SHRs that received injection of THP. Direct injection of THP into brain lowered the blood pressure and plasma noradrenaline. This antihypertensive action of THP appears to be produced mainly by an effect on central nervous system to lower sympathetic tone in SHRs.",

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year = "1996",

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T1 - Antihypertensive Activity of dl-Tetrahydropalmatine, an Active Alkaloid Isolated from the Tubers of Corydalis racemosa

AU - Chu, Lian Hwa

AU - Hsu, Feng Lin

AU - Chueh, Fu Yu

AU - Niu, Chiang Shan

AU - Cheng, Juei Tang

PY - 1996

Y1 - 1996

N2 - The antihypertensive activity of dl-tetrahydropalmatine hydrochloride (THP), isolated from the tubers of Corydalis racemosa (Thunb.) Pers. (Papaveraceae), was investigated in spontaneously hypertensive rats (SHRs) using intravenous injection. A dose-dependent lowering of blood pressure was observed in SHRs. Decrease of plasma noradrenaline was also obtained in SHRs that received injection of THP. Direct injection of THP into brain lowered the blood pressure and plasma noradrenaline. This antihypertensive action of THP appears to be produced mainly by an effect on central nervous system to lower sympathetic tone in SHRs.

AB - The antihypertensive activity of dl-tetrahydropalmatine hydrochloride (THP), isolated from the tubers of Corydalis racemosa (Thunb.) Pers. (Papaveraceae), was investigated in spontaneously hypertensive rats (SHRs) using intravenous injection. A dose-dependent lowering of blood pressure was observed in SHRs. Decrease of plasma noradrenaline was also obtained in SHRs that received injection of THP. Direct injection of THP into brain lowered the blood pressure and plasma noradrenaline. This antihypertensive action of THP appears to be produced mainly by an effect on central nervous system to lower sympathetic tone in SHRs.

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DO - 10.1002/jccs.199600071

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AN - SCOPUS:0013563033

SN - 0009-4536

VL - 43

SP - 489

EP - 492

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 6

ER -

Antihypertensive Activity of dl-Tetrahydropalmatine, an Active Alkaloid Isolated from the Tubers of Corydalis racemosa

Abstract

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