Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis

Yang Che Wu, Yu Hsueh Wu, Yi Ping Wang, Julia Yu Fong Chang, Hsin Ming Chen, Andy Sun

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Background/Purpose Anti-gastric parietal cell antibody (GPCA), anti-thyroglobulin antibody (TGA), and anti-thyroid microsomal antibody (TMA) have not yet been reported in patients with recurrent aphthous stomatitis (RAS). This study mainly assessed the frequencies of the presence of serum GPCA, TGA, and TMA in different types of RAS patients. Methods Serum GPCA, TGA, and TMA levels were measured in 355 RAS patients of different subtypes and in 355 age- and sex-matched healthy control individuals. Results We found that 13.0%, 19.4%, and 19.7% of 355 RAS patients, 16.7%, 23.3%, and 21.7% of 60 major-typed RAS patients, 12.2%, 18.6%, and 19.3% of 295 minor-typed RAS patients, 18.1%, 20.0%, and 21.9% of 160 atrophic glossitis-positive RAS (AG+/RAS) patients, and 8.7%, 19.0%, and 17.9% of 195 AG-negative RAS (AG–/RAS) patients had the presence of GPCA, TGA, and TMA in their sera, respectively. RAS, major-typed RAS, minor-typed RAS, AG+/RAS, and AG–/RAS patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control individuals (all p < 0.001). Of 65 TGA/TMA-positive RAS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 76.9%, 12.3%, and 10.8% of these TGA/TMA-positive RAS patients had normal, lower, and higher serum TSH levels, respectively. Conclusion We conclude that approximately one-third RAS patients may have GPCA/TGA/TMA positivity in their sera. Because some GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and some TGA/TMA-positive patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these patients should be referred to doctors for further management.

Original languageEnglish
Pages (from-to)4-9
Number of pages6
JournalJournal of the Formosan Medical Association
Issue number1
Publication statusPublished - Jan 1 2017
Externally publishedYes


  • antigastric parietal cell antibody
  • antithyroglobulin antibody
  • antithyroid microsomal antibody
  • atrophic glossitis
  • recurrent aphthous stomatitis

ASJC Scopus subject areas

  • General Medicine


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