Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica

Chia Chung Hou; Shwu Jiuan Lin; Juei Tang Cheng; Feng-Lin Hsu

doi:10.1021/np0205349

Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica

Chia Chung Hou, Shwu Jiuan Lin, Juei Tang Cheng, Feng-Lin Hsu

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Three novel sesquiterpene lactones, lactucain A (1), B (2), and C (3), and a new furofuran lignan, lactucaside (4), were isolated from Lactuca indica along with nine known compounds, 11β,13-dihydrolactucin, cichoriosides B, quercetin, quercetin 3-O-glucoside, rutin, apigenin, luteolin, luteolin 7-O-glucuronide, and chlorogenic acid. Among these compounds, latucain C (3) and lactucaside (4) showed significant antidiabetic activity.

Original language	English
Pages (from-to)	625-629
Number of pages	5
Journal	Journal of Natural Products
Volume	66
Issue number	5
DOIs	https://doi.org/10.1021/np0205349
Publication status	Published - May 1 2003

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica",

abstract = "Three novel sesquiterpene lactones, lactucain A (1), B (2), and C (3), and a new furofuran lignan, lactucaside (4), were isolated from Lactuca indica along with nine known compounds, 11β,13-dihydrolactucin, cichoriosides B, quercetin, quercetin 3-O-glucoside, rutin, apigenin, luteolin, luteolin 7-O-glucuronide, and chlorogenic acid. Among these compounds, latucain C (3) and lactucaside (4) showed significant antidiabetic activity.",

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AU - Hou, Chia Chung

AU - Lin, Shwu Jiuan

AU - Cheng, Juei Tang

AU - Hsu, Feng-Lin

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Three novel sesquiterpene lactones, lactucain A (1), B (2), and C (3), and a new furofuran lignan, lactucaside (4), were isolated from Lactuca indica along with nine known compounds, 11β,13-dihydrolactucin, cichoriosides B, quercetin, quercetin 3-O-glucoside, rutin, apigenin, luteolin, luteolin 7-O-glucuronide, and chlorogenic acid. Among these compounds, latucain C (3) and lactucaside (4) showed significant antidiabetic activity.

AB - Three novel sesquiterpene lactones, lactucain A (1), B (2), and C (3), and a new furofuran lignan, lactucaside (4), were isolated from Lactuca indica along with nine known compounds, 11β,13-dihydrolactucin, cichoriosides B, quercetin, quercetin 3-O-glucoside, rutin, apigenin, luteolin, luteolin 7-O-glucuronide, and chlorogenic acid. Among these compounds, latucain C (3) and lactucaside (4) showed significant antidiabetic activity.

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Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica

Abstract

ASJC Scopus subject areas

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