Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica

Chia Chung Hou, Shwu Jiuan Lin, Juei Tang Cheng, Feng-Lin Hsu

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71 Citations (Scopus)


Three novel sesquiterpene lactones, lactucain A (1), B (2), and C (3), and a new furofuran lignan, lactucaside (4), were isolated from Lactuca indica along with nine known compounds, 11β,13-dihydrolactucin, cichoriosides B, quercetin, quercetin 3-O-glucoside, rutin, apigenin, luteolin, luteolin 7-O-glucuronide, and chlorogenic acid. Among these compounds, latucain C (3) and lactucaside (4) showed significant antidiabetic activity.

Original languageEnglish
Pages (from-to)625-629
Number of pages5
JournalJournal of Natural Products
Issue number5
Publication statusPublished - May 1 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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