TY - JOUR
T1 - Anti-lymphangiogenic diterpenes from the bark of Calocedrus macrolepis var. formosana.
AU - Lee, Tzong-Huei
AU - Hsieh, Chin-Lin
AU - Wu, Ho-Cheng
AU - Wang, Shih-Wei
AU - Yu, Chen-Lin
AU - Hsiao, George
AU - Cheng, Ming-Jen
AU - Hsieh, Wen-Tsong
AU - Kuo, Yueh-Hsiung
N1 - Accession Number: 154366851. Language: English. Entry Date: 20220107. Revision Date: 20220121. Publication Type: Article; pictorial; research; tables/charts. Journal Subset: Asia; Biomedical. NLM UID: 9425219.
PY - 2021/10
Y1 - 2021/10
N2 - Eight new diterpenes, 6α,7β-dihydroxyferruginol (1), 6α,7α-dihydroxyferruginol (2), 6α-hydroxyhinokiol (3), 4α-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4α-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7α-acetoxyabieta-8,12-diene-11,14-dione (7), 7α-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along with four known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7α-11-dihy- droxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolated from the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data (appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12 showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds, compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs. In conclusion, the results revealed the anti-lymphangiogenic potentials of Formosan C. macrolepis var. formosana.
AB - Eight new diterpenes, 6α,7β-dihydroxyferruginol (1), 6α,7α-dihydroxyferruginol (2), 6α-hydroxyhinokiol (3), 4α-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4α-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7α-acetoxyabieta-8,12-diene-11,14-dione (7), 7α-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along with four known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7α-11-dihy- droxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolated from the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data (appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12 showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds, compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs. In conclusion, the results revealed the anti-lymphangiogenic potentials of Formosan C. macrolepis var. formosana.
KW - Hydrocarbons -- Analysis
KW - Plant Bark
KW - Plants, Medicinal
KW - Antineoplastic Agents
KW - Human
KW - Endothelial Cells
KW - Terpenes -- Analysis
KW - Magnetic Resonance Spectroscopy
KW - Molecular Structure
U2 - 10.38212/2224-6614.3375
DO - 10.38212/2224-6614.3375
M3 - 文章
SN - 1021-9498
VL - 29
SP - 606
EP - 621
JO - Journal of Food and Drug Analysis
JF - Journal of Food and Drug Analysis
IS - 4
ER -