TY - JOUR
T1 - Anti-inflammatory effects of resveratrol and oligostilbenes from vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis
AU - Wang, Kun Teng
AU - Chen, Lih Geeng
AU - Tseng, Sung Hui
AU - Huang, Jung Shan
AU - Hsieh, Ming-Shium
AU - Wang, Ching Chiung
PY - 2011/4/27
Y1 - 2011/4/27
N2 - Vitis thunbergii Sieb. and Zucc. var. taiwaniana Lu is an endemic plant in Taiwan used as a dietary supplement for bone health. In this study, human chondrocytes were induced to produce COX-2, MMP-3, -13, and PGE2 by LPS. An 18F-FDG microPET imaging system was used to evaluate the anti-inflammatory arthritic effects in vivo. Six stilbenes, resveratrol (1), (+)-μ-viniferin (2), ampelopsin C (3), ampelopsin A (4), (-)-vitisin B (5), and (+)-vitisin A (6), were isolated from the stem part of V. thunbergii, which displayed the strongest PGE2 inhibition. Among these compounds, 1 significantly decreased COX-2 activity, PGE2, MMP-3, and -13 production in vitro, and 18F-FDG uptake and serum PGE2 in rabbits in vivo. Anti-inflammatory effects were enhanced through the combined usage of 1 and other oligostilbenes. Taken together, the synergistic effects of 1 and oligostilbenes resulted in stem part extracts with lower 1 content displaying the better anti-inflammatory arthritis effects.
AB - Vitis thunbergii Sieb. and Zucc. var. taiwaniana Lu is an endemic plant in Taiwan used as a dietary supplement for bone health. In this study, human chondrocytes were induced to produce COX-2, MMP-3, -13, and PGE2 by LPS. An 18F-FDG microPET imaging system was used to evaluate the anti-inflammatory arthritic effects in vivo. Six stilbenes, resveratrol (1), (+)-μ-viniferin (2), ampelopsin C (3), ampelopsin A (4), (-)-vitisin B (5), and (+)-vitisin A (6), were isolated from the stem part of V. thunbergii, which displayed the strongest PGE2 inhibition. Among these compounds, 1 significantly decreased COX-2 activity, PGE2, MMP-3, and -13 production in vitro, and 18F-FDG uptake and serum PGE2 in rabbits in vivo. Anti-inflammatory effects were enhanced through the combined usage of 1 and other oligostilbenes. Taken together, the synergistic effects of 1 and oligostilbenes resulted in stem part extracts with lower 1 content displaying the better anti-inflammatory arthritis effects.
KW - F-FDG microPET
KW - inflammatory arthritis
KW - oligostilbenes
KW - resveratrol
KW - synergistic effects
KW - Vitis thunbergii var. taiwaniana
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U2 - 10.1021/jf104718g
DO - 10.1021/jf104718g
M3 - Article
C2 - 21391605
AN - SCOPUS:79955000199
SN - 0021-8561
VL - 59
SP - 3649
EP - 3656
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 8
ER -
