Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis

Te An Kung, Lo Yun Chen, Chia Ying Li, Bo Rong Peng, Tsong Long Hwang, Ping Jyun Sung, Kuei Hung Lai, Hsu Ming Chung

Research output: Contribution to journalArticlepeer-review


The exploration of Sinularia querciformis cembranoids afforded two new compounds, querciformolide G (1) and H (2), along with three known ones, sinulaparvalide (3), sinulariolone acetate (4), and 3,4:8,11-bisepoxy-7-hydroxycembra-15(17)-en-1,12-olide (5). The structural elucidation of these compounds was achieved by extensive spectroscopic (IR, ESIMS, 1D and 2D NMR data) analysis and by comparison with those previously reported in the literature. Compounds 1–5 were evaluated for their anti-inflammatory activity. Among all, compound 1 displayed significant inhibitory effects on the elastase release in activated human neutrophils.

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalPhytochemistry Letters
Publication statusPublished - Jun 2023


  • Anti-inflammation
  • Cembranoid
  • Elastase release
  • Sinularia querciformis

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science


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