Anti-inflammatory and antiviral activities of flavone C-glycosides of Lophatherum gracile for COVID-19

Yu Li Chen, Chun Yu Chen, Kuei Hung Lai, Yu Chia Chang, Tsong Long Hwang

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Lophatherum gracile (L. gracile) has long been used as a functional food and herbal medicine. Previous studies have demonstrated that extracts of L. gracile attenuate inflammatory response and inhibit SARS-CoV-2 replication; however, the underlying active constituents have yet to be identified. This study investigated the bioactive components of L. gracile. Flavone C-glycosides of L. gracile were found to dominate both anti-inflammatory and antiviral effects. A simple chromatography-based method was developed to obtain flavone C-glycoside-enriched extract (FlavoLG) from L. gracile. FlavoLG and its major flavone C-glycoside isoorientin were shown to restrict respiratory bursts and the formation of neutrophil extracellular traps in activated human neutrophils. FlavoLG and isoorientin were also shown to inhibit SARS-CoV-2 pseudovirus infection by interfering with the binding of the SARS-CoV-2 spike on ACE2. These results provide scientific evidence indicating the efficacy of L. gracile as a potential supplement for treating neutrophil-associated COVID-19.

Original languageEnglish
Article number105407
JournalJournal of Functional Foods
Publication statusPublished - Feb 2023


  • COVID-19
  • Flavone C-glycosides
  • Lophatherum gracile
  • Neutrophils
  • SARS-CoV-2

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics


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