Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs

Yu Tang Tung, Meng Thong Chua, Sheng Yang Wang, Shang Tzen Chang

Research output: Contribution to journalArticlepeer-review

298 Citations (Scopus)


In this study, chemical compositions of hydrodistilled essential oil and anti-inflammatory activities from the twigs of Cinnamomum osmophloeum Kaneh. were investigated for the first time. The chemical constituents of the twig essential oil were further analyzed by GC-MS and they were found to be l-bornyl acetate (15.89%), caryophyllene oxide (12.98%), γ-eudesmol (8.03%), β-caryophyllene (6.60%), T-cadinol (5.49%), δ-cadinene (4.79%), trans-β-elemenone (4.25%), cadalene (4.19%), and trans-cinnamaldehyde (4.07%). The effects of essential oil on nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. Results of nitric oxide tests indicated that twig essential oil and its major constituents such as trans-cinnamaldehyde, caryophyllene oxide, l-borneol, l-bornyl acetate, eugenol, β-caryophyllene, E-nerolidol, and cinnamyl acetate have excellent activities. These findings demonstrated that essential oil of C. osmophloeum twigs have excellent anti-inflammatory activities and thus have great potential to be used as a source for natural health products.

Original languageEnglish
Pages (from-to)3908-3913
Number of pages6
JournalBioresource Technology
Issue number9
Publication statusPublished - Jun 2008
Externally publishedYes


  • Anti-inflammation
  • Cinnamomum osmophloeum
  • Essential oil
  • trans-Cinnamaldehyde
  • Twigs

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Food Science
  • Process Chemistry and Technology
  • Applied Microbiology and Biotechnology


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