Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy

H. S. Liu; H. W. Chung; C. J. Juan; S. Y. Tsai; C. Y. Wang; C. C. Chan; G. S. Huang; M. C. Chou; C. S. Lee; C. W. Ko; N. Y. Cho; Cheng Yu Chen

doi:10.3174/ajnr.A1131

Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy

H. S. Liu, H. W. Chung, C. J. Juan, S. Y. Tsai, C. Y. Wang, C. C. Chan, G. S. Huang, M. C. Chou, C. S. Lee, C. W. Ko, N. Y. Cho, Cheng Yu Chen

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved ¹H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.

Original language	English
Pages (from-to)	1644-1648
Number of pages	5
Journal	American Journal of Neuroradiology
Volume	29
Issue number	9
DOIs	https://doi.org/10.3174/ajnr.A1131
Publication status	Published - Oct 2008
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Radiology Nuclear Medicine and imaging

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title = "Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy",

abstract = "The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved 1H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.",

author = "Liu, {H. S.} and Chung, {H. W.} and Juan, {C. J.} and Tsai, {S. Y.} and Wang, {C. Y.} and Chan, {C. C.} and Huang, {G. S.} and Chou, {M. C.} and Lee, {C. S.} and Ko, {C. W.} and Cho, {N. Y.} and Chen, {Cheng Yu}",

year = "2008",

month = oct,

doi = "10.3174/ajnr.A1131",

language = "English",

volume = "29",

pages = "1644--1648",

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TY - JOUR

T1 - Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy

AU - Liu, H. S.

AU - Chung, H. W.

AU - Juan, C. J.

AU - Tsai, S. Y.

AU - Wang, C. Y.

AU - Chan, C. C.

AU - Huang, G. S.

AU - Chou, M. C.

AU - Lee, C. S.

AU - Ko, C. W.

AU - Cho, N. Y.

AU - Chen, Cheng Yu

PY - 2008/10

Y1 - 2008/10

N2 - The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved 1H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.

AB - The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved 1H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.

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SN - 0195-6108

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JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

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ER -

Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy

Abstract

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