Anodized biomedical stainless-steel mini-implant for rapid recovery in a rabbit model

Yung Chieh Cho, Wei Chiang Hung, Wen Chien Lan, Takashi Saito, Bai Hung Huang, Chen Han Lee, Hsin Yu Tsai, Mao Suan Huang, Keng Liang Ou

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The study aimed to analyze the recovery period of the anodized 316L biomedical stainless steel (BSS) mini-implant through its implantation on femur of rabbit model. The 316L BSS miniimplant was modified by an electrochemical anodization approach with different voltages. The anodized samples were characterized via field-emission scanning electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. The biocompatibility was assessed by cell culture assay. The anodized mini-implant was implanted on rabbit’s femur then evaluated histologically after 4 and 8 weeks. Analytical results indicated that the topography of the anodized mini-implant at 5 V for 5 min consisted of a dual (micro/nano) porous structure. Oxide film of Cr2O3 was formed on the surface of anodized mini-implant after anodizing with 5 V for 5 min. In vitro cell culture assay revealed that fibroblast cells (NIH-3T3) on the anodized samples were more firmly attached as compared with the control sample. Moreover, histological analysis demonstrated that the anodized mini-implant improved bone recovering at 4 weeks after implantation. Thus, this study suggests that the anodized 316L BSS mini-implant could be a potential choice as anchorage device for effective and efficient orthodontic treatment.

Original languageEnglish
Article number1575
Issue number10
Publication statusPublished - Oct 2021


  • Anodization
  • Biocompatibility
  • Biomedical stainless-steel
  • Mini-implant
  • Stability

ASJC Scopus subject areas

  • Materials Science(all)
  • Metals and Alloys


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