Annexin A2: Its molecular regulation and cellular expression in cancer development

Chi Yun Wang; Chiou Feng Lin

doi:10.1155/2014/308976

Annexin A2: Its molecular regulation and cellular expression in cancer development

Chi Yun Wang, Chiou Feng Lin

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Abstract

Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management.

Original language	English
Article number	308976
Journal	Disease Markers
Volume	2014
DOIs	https://doi.org/10.1155/2014/308976
Publication status	Published - 2014

ASJC Scopus subject areas

Molecular Biology
Genetics
Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1155/2014/308976

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Annexin A2: Its molecular regulation and cellular expression in cancer development

Abstract

ASJC Scopus subject areas

UN SDGs

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