ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis

Po I. Liu; Ya Jing Jiang; An Chen Chang; Chang Lun Huang; Yi Chin Fong; Jeng Hung Guo; Chun Lin Liu; Shih Wei Wang; Ju Fang Liu; Sunny Li Yu Chang; Chih Hsin Tang

doi:10.18632/aging.204581

ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis

Po I. Liu, Ya Jing Jiang, An Chen Chang, Chang Lun Huang, Yi Chin Fong, Jeng Hung Guo, Chun Lin Liu, Shih Wei Wang, Ju Fang Liu, Sunny Li Yu Chang, Chih Hsin Tang

School of Oral Hygiene

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Lung cancer is an extremely common cancer and metastatic lung cancer has a greatly low survival rate. Lymphangiogenesis is essential for the development and metastasis of lung cancer. The adipokine angiopoietin-like protein 2 (ANGPTL2) regulates tumor progression and metastasis, although the functions of ANGPTL2 in lung cancer are unknown. Analysis of data from TCGA genomics program, the GEPIA web server and the Oncomine database revealed that higher levels of ANGPTL2 expression were correlated with progressive disease and lymph node metastasis. ANGPTL2 enhanced VEGF-A-dependent lymphatic endothelial cell (LEC) tube formation and migration. Integrin α5β1, p38 and nuclear factor (NF)-κB signaling mediated ANGPTL2-regulated lymphangiogenesis. Importantly, overexpression ANGPTL2 facilitated tumor growth and lymphangiogenesis in vivo.

Original language	English
Pages (from-to)	1652-1667
Number of pages	16
Journal	Aging
Volume	15
Issue number	5
DOIs	https://doi.org/10.18632/aging.204581
Publication status	Published - 2023

Keywords

ANGPTL2
LEC
lung cancer
lymphangiogenesis
VEGF-A

ASJC Scopus subject areas

Ageing
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/aging.204581

Cite this

@article{39263eeaaa784fa59be073eb2ad3db94,

title = "ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis",

abstract = "Lung cancer is an extremely common cancer and metastatic lung cancer has a greatly low survival rate. Lymphangiogenesis is essential for the development and metastasis of lung cancer. The adipokine angiopoietin-like protein 2 (ANGPTL2) regulates tumor progression and metastasis, although the functions of ANGPTL2 in lung cancer are unknown. Analysis of data from TCGA genomics program, the GEPIA web server and the Oncomine database revealed that higher levels of ANGPTL2 expression were correlated with progressive disease and lymph node metastasis. ANGPTL2 enhanced VEGF-A-dependent lymphatic endothelial cell (LEC) tube formation and migration. Integrin α5β1, p38 and nuclear factor (NF)-κB signaling mediated ANGPTL2-regulated lymphangiogenesis. Importantly, overexpression ANGPTL2 facilitated tumor growth and lymphangiogenesis in vivo.",

keywords = "ANGPTL2, LEC, lung cancer, lymphangiogenesis, VEGF-A",

author = "Liu, {Po I.} and Jiang, {Ya Jing} and Chang, {An Chen} and Huang, {Chang Lun} and Fong, {Yi Chin} and Guo, {Jeng Hung} and Liu, {Chun Lin} and Wang, {Shih Wei} and Liu, {Ju Fang} and Chang, {Sunny Li Yu} and Tang, {Chih Hsin}",

note = "Funding Information: This study was supported by grants from Taiwan{\textquoteright}s Ministry of Science and Technology (MOST 110-2320-B-039-022-MY3); China Medical University Hospital (DMR-111-164; DMR-111-108; DMR-111-229; DMR-112-077; DMR-112-081); Asia University Hospital (11051008); Changhua Christian Hospital (108-CCH-IRP-028; National Science and Technology Council (NSTC 111-2320-B-468-006-). Publisher Copyright: {\textcopyright} 2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited",

year = "2023",

doi = "10.18632/aging.204581",

language = "English",

volume = "15",

pages = "1652--1667",

journal = "Aging",

issn = "1945-4589",

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TY - JOUR

T1 - ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis

AU - Liu, Po I.

AU - Jiang, Ya Jing

AU - Chang, An Chen

AU - Huang, Chang Lun

AU - Fong, Yi Chin

AU - Guo, Jeng Hung

AU - Liu, Chun Lin

AU - Wang, Shih Wei

AU - Liu, Ju Fang

AU - Chang, Sunny Li Yu

AU - Tang, Chih Hsin

N1 - Funding Information: This study was supported by grants from Taiwan’s Ministry of Science and Technology (MOST 110-2320-B-039-022-MY3); China Medical University Hospital (DMR-111-164; DMR-111-108; DMR-111-229; DMR-112-077; DMR-112-081); Asia University Hospital (11051008); Changhua Christian Hospital (108-CCH-IRP-028; National Science and Technology Council (NSTC 111-2320-B-468-006-). Publisher Copyright: © 2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

PY - 2023

Y1 - 2023

N2 - Lung cancer is an extremely common cancer and metastatic lung cancer has a greatly low survival rate. Lymphangiogenesis is essential for the development and metastasis of lung cancer. The adipokine angiopoietin-like protein 2 (ANGPTL2) regulates tumor progression and metastasis, although the functions of ANGPTL2 in lung cancer are unknown. Analysis of data from TCGA genomics program, the GEPIA web server and the Oncomine database revealed that higher levels of ANGPTL2 expression were correlated with progressive disease and lymph node metastasis. ANGPTL2 enhanced VEGF-A-dependent lymphatic endothelial cell (LEC) tube formation and migration. Integrin α5β1, p38 and nuclear factor (NF)-κB signaling mediated ANGPTL2-regulated lymphangiogenesis. Importantly, overexpression ANGPTL2 facilitated tumor growth and lymphangiogenesis in vivo.

AB - Lung cancer is an extremely common cancer and metastatic lung cancer has a greatly low survival rate. Lymphangiogenesis is essential for the development and metastasis of lung cancer. The adipokine angiopoietin-like protein 2 (ANGPTL2) regulates tumor progression and metastasis, although the functions of ANGPTL2 in lung cancer are unknown. Analysis of data from TCGA genomics program, the GEPIA web server and the Oncomine database revealed that higher levels of ANGPTL2 expression were correlated with progressive disease and lymph node metastasis. ANGPTL2 enhanced VEGF-A-dependent lymphatic endothelial cell (LEC) tube formation and migration. Integrin α5β1, p38 and nuclear factor (NF)-κB signaling mediated ANGPTL2-regulated lymphangiogenesis. Importantly, overexpression ANGPTL2 facilitated tumor growth and lymphangiogenesis in vivo.

KW - ANGPTL2

KW - LEC

KW - lung cancer

KW - lymphangiogenesis

KW - VEGF-A

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ER -

ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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