Abstract
The study was conducted to examine the effects of the angiotensin subtype 1 and 2 receptor antagonists (losartan and PD123319, respectively) on blood pressure (BP) and renal excretory function in chronic hyperinsulinemia- induced hypertension in rats. Hyperinsulinemia was achieved by insulin infusion (21.5 pmol/kg per minute) via osmotic minipump for 6 weeks. Losartan or PD 123319 was coinfused either at the beginning or after 4 weeks of insulin infusion. The results showed that insulin infusion significantly increased the plasma insulin concentration from 259.0±22.2 to 646.5±33.0 and 713.9±26.5 pmol/L (P
| Original language | English |
|---|---|
| Pages (from-to) | 235-242 |
| Number of pages | 8 |
| Journal | Hypertension |
| Volume | 32 |
| Issue number | 2 |
| Publication status | Published - Aug 1998 |
| Externally published | Yes |
Keywords
- Angiotensin receptor antagonist
- Hyperinsulinemia
- Insulin resistance
- Losartan
- PD123319
ASJC Scopus subject areas
- Internal Medicine