Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

Chin Hung Liu; Jin Ding Huang; Shi Wei Huang; Tzyh Chyuan Hour; Yung Kai Huang; Yu Mei Hsueh; Hung Yi Chiou; Te Chang Lee; Kun Yan Jan; Chien Jen Chen; Yeong Shiau Pu

doi:10.1007/s11373-007-9215-x

Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

Chin Hung Liu, Jin Ding Huang, Shi Wei Huang, Tzyh Chyuan Hour, Yung Kai Huang, Yu Mei Hsueh, Hung Yi Chiou, Te Chang Lee, Kun Yan Jan, Chien Jen Chen, Yeong Shiau Pu

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (

Original language	English
Pages (from-to)	261-269
Number of pages	9
Journal	Journal of Biomedical Science
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s11373-007-9215-x
Publication status	Published - Mar 2008

Keywords

Bladder neoplasms
Carcinogenesis
Tobacco
Trinucleotide repeats
Urinary tract

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Molecular Biology
Clinical Biochemistry
Cell Biology
Biochemistry, medical
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11373-007-9215-x

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title = "Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma",

abstract = "The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (",

keywords = "Bladder neoplasms, Carcinogenesis, Tobacco, Trinucleotide repeats, Urinary tract",

author = "Liu, {Chin Hung} and Huang, {Jin Ding} and Huang, {Shi Wei} and Hour, {Tzyh Chyuan} and Huang, {Yung Kai} and Hsueh, {Yu Mei} and Chiou, {Hung Yi} and Lee, {Te Chang} and Jan, {Kun Yan} and Chen, {Chien Jen} and Pu, {Yeong Shiau}",

note = "Funding Information: This study was supported by grants (91GMP012-3 and 91GMP012-4) from the National Science Council, Executive Yuan, Republic of China.",

year = "2008",

month = mar,

doi = "10.1007/s11373-007-9215-x",

language = "English",

volume = "15",

pages = "261--269",

journal = "Journal of Biomedical Science",

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T1 - Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

AU - Liu, Chin Hung

AU - Huang, Jin Ding

AU - Huang, Shi Wei

AU - Hour, Tzyh Chyuan

AU - Huang, Yung Kai

AU - Hsueh, Yu Mei

AU - Chiou, Hung Yi

AU - Lee, Te Chang

AU - Jan, Kun Yan

AU - Chen, Chien Jen

AU - Pu, Yeong Shiau

N1 - Funding Information: This study was supported by grants (91GMP012-3 and 91GMP012-4) from the National Science Council, Executive Yuan, Republic of China.

PY - 2008/3

Y1 - 2008/3

N2 - The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (

AB - The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (

KW - Bladder neoplasms

KW - Carcinogenesis

KW - Tobacco

KW - Trinucleotide repeats

KW - Urinary tract

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Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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