Analyzing mortality risk and medical burden among patients with traumatic brain injury and subsequent dementia

Dorji Harnod, Tomor Harnod, Cheng Li Lin, Chia Hung Kao

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We used the National Health Insurance Research Database of Taiwan to determine whether patients with posttraumatic dementia (PTD) exhibit increased mortality and medical burden than those without it. Patients ≥20 years of age having head injury admission (per the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 850–854, 959.01) between 2000 and 2012 were enrolled as traumatic brain injury (TBI) cohort. A PTD cohort (with ICD-9-CM codes 290, 294.1, 331.0) and a posttraumatic nondementia (PTN) cohort were established and compared in terms of age, sex, and comorbidities. We calculated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of all-cause mortality risk, number of hospital days, and frequency of medical visits in these cohorts. Patients with PTD had a higher mortality rate than did patients with TBI alone (rate per 1000 person-years: 12.00 vs. 6.32), with an aHR of 1.54 (95% CI: 1.32–1.80). Patients with PTD who were aged ≥65 years (aHR = 1.54, 95% CI: 1.31–1.80) or male (aHR = 1.78, 95% CI: 1.45–2.18) exhibited greatly increased risks of mortality. Furthermore, patients with PTD had 19.9 more hospital days and required medical visits 4.49 times more frequently compared with the PTN cohort. Taiwanese patients with PTD had increased mortality risk and medical burden compared with patients who had TBI only. Our findings provide crucial information for clinicians and the government to improve TBI and PTD outcomes.

Original languageEnglish
Article number686
JournalJournal of Clinical Medicine
Volume8
Issue number5
DOIs
Publication statusPublished - May 2019
Externally publishedYes

Keywords

  • Cohort study
  • Mortality
  • National health insurance
  • Posttraumatic dementia
  • Traumatic brain injury

ASJC Scopus subject areas

  • General Medicine

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