TY - GEN
T1 - Analysis of UHMWPE particle shape effects on bioactivity from the physical viewpoint of phagocytosis process
AU - Fang, H. W.
AU - Hsu, S. M.
AU - Sengers, J. V.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - Biophysical principles were applied to calculate the maximum number of ultra-high molecular weight polyethylene (UHMWPE) particles that can be phagocytosed for various size and shapes of particles. It was assumed that the particle has an ellipsoidal shape with one longer and two equal shorter axes. It was found that, with the same total particle volume, elongated particles gather more macrophage cells in the phagocytosis process. It was also found that smaller particles within the phagocytosable range induce stronger bioactivity than large particles that cannot be engulfed by the macrophage cells.
AB - Biophysical principles were applied to calculate the maximum number of ultra-high molecular weight polyethylene (UHMWPE) particles that can be phagocytosed for various size and shapes of particles. It was assumed that the particle has an ellipsoidal shape with one longer and two equal shorter axes. It was found that, with the same total particle volume, elongated particles gather more macrophage cells in the phagocytosis process. It was also found that smaller particles within the phagocytosable range induce stronger bioactivity than large particles that cannot be engulfed by the macrophage cells.
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M3 - Conference contribution
AN - SCOPUS:13844296568
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -