Analysis of the mechanism of tumor metastasis by the transfection of integrin cDNA

N. Matsuura, E. Tashita, J. Yamamura, Y. Kagawa, Y. Takada

Research output: Contribution to journalReview articlepeer-review


Integrin plays an important role in tumor metastasis through its interaction with extracellular matrix and endothelial cell. We have examined the role of each integrin in tumor metastasis by using transfection of integrin cDNA into various cells. Transfection of integrin alpha 2 subunit into RD cells, human rhabdomyosarcoma cells which do not express integrin alpha 2 beta 1, potentiated the frequency of metastases in various organs; lung, bone, adrenal gland, lymph node. alpha 4-transfectant of Chinese hamster ovary (CHO) cells, which do not have alpha 4 beta 1 on the cell surface, metastasized to bone through its interaction with VCAM-1 in the bone marrow stroma cells. On the other hand, alpha 5-transfectant of CHO cells was much less tumorgenic than parent CHO cells. These data suggest integrin influence tumor metastasis sometimes favorably and sometimes unfavorably according to the activity and the balance of various integrins.

Original languageEnglish
Pages (from-to)1643-1647
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number7
Publication statusPublished - Jul 1995
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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