Analysis of risk factors for central venous port failure in cancer patients

Ching Chuan Hsieh, Hsu Huei Weng, Wen Shih Huang, Wen Ke Wang, Chiung Lun Kao, Ming Shian Lu, Chia Siu Wang

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (TIVADs) were implanted into 1280 cancer patients in this cohort study. A Cox proportional hazard model was applied to analyze risk factors for failure of TIVADs. Log-rank test was used to compare actuarial survival rates. Infection, thrombosis, and surgical complication rates (χ2 test or Fisher's exact test) were compared in relation to the risk factors. RESULTS: Increasing age, male gender and open-ended catheter use were significant risk factors reducing survival of TIVADs as determined by univariate and multivariate analyses. Hematogenous malignancy decreased the survival time of TIVADs; this reduction was not statistically significant by univariate analysis [hazard ratio (HR) = 1.336, 95% CI: 0.966-1.849, P = 0.080)]. However, it became a significant risk factor by multivariate analysis (HR = 1.499, 95% CI: 1.079-2.083, P = 0.016) when correlated with variables of age, sex and catheter type. Close-ended (Groshong) catheters had a lower thrombosis rate than open-ended catheters (2.5% vs 5%, P = 0.015). Hematogenous malignancy had higher infection rates than solid malignancy (10.5% vs 2.5%, P < 0.001). CONCLUSION: Increasing age, male gender, open-ended catheters and hematogenous malignancy were risk factors for TIVAD failure. Close-ended catheters had lower thrombosis rates and hematogenous malignancy had higher infection rates.

Original languageEnglish
Pages (from-to)4709-4714
Number of pages6
JournalWorld Journal of Gastroenterology
Issue number37
Publication statusPublished - Dec 16 2009
Externally publishedYes


  • Cancer patient
  • Central venous port
  • Chemotherapy
  • Multivariate analysis
  • Risk factor

ASJC Scopus subject areas

  • Gastroenterology


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