Analysis of cell ratio and drug concentration influence in feigning lung cancer model

Kuo Wei Chang; Tse Shao Chen; Shilpa Sivashankar; Ming Yan Chen; Kang Yun Lee; Cheng Hsien Liu

doi:10.1109/Transducers.2013.6626779

Analysis of cell ratio and drug concentration influence in feigning lung cancer model

Kuo Wei Chang, Tse Shao Chen, Shilpa Sivashankar, Ming Yan Chen, Kang Yun Lee, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Here presented is an integrated drug testing system based on a mimetic lung tissue pattern of in vitro targeted therapy testing. The integrated targeted therapy testing system consists of continuous concentration gradient platform and dielectrophoretic (DEP) cell patterning chambers. DEP forces are based on polarity difference to manipulate heterogeneous cells for mimicking the inherent lung morphology and increasing the cell-cell interaction. The multiplexed microchannels allow for simultaneous administration of multiple drug doses to functional lung cancer cells while an incorporated concentration gradient enables the in vitro dose-dependent drug responses to predict in vivo hepatotoxicity.

Original language	English
Title of host publication	2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Pages	369-372
Number of pages	4
DOIs	https://doi.org/10.1109/Transducers.2013.6626779
Publication status	Published - 2013
Externally published	Yes
Event	2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 - Barcelona, Spain Duration: Jun 16 2013 → Jun 20 2013

Other

Other	2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Country/Territory	Spain
City	Barcelona
Period	6/16/13 → 6/20/13

Keywords

dielectrophoretic (DEP)
gradient microchannel
Lung cancer
patterned
targeted therapy

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/Transducers.2013.6626779

Cite this

Chang, K. W., Chen, T. S., Sivashankar, S., Chen, M. Y., Lee, K. Y., & Liu, C. H. (2013). Analysis of cell ratio and drug concentration influence in feigning lung cancer model. In 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 (pp. 369-372). Article 6626779 https://doi.org/10.1109/Transducers.2013.6626779

Analysis of cell ratio and drug concentration influence in feigning lung cancer model. / Chang, Kuo Wei; Chen, Tse Shao; Sivashankar, Shilpa et al.
2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013. 2013. p. 369-372 6626779.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chang, KW, Chen, TS, Sivashankar, S, Chen, MY, Lee, KY & Liu, CH 2013, Analysis of cell ratio and drug concentration influence in feigning lung cancer model. in 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013., 6626779, pp. 369-372, 2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013, Barcelona, Spain, 6/16/13. https://doi.org/10.1109/Transducers.2013.6626779

Chang KW, Chen TS, Sivashankar S, Chen MY, Lee KY, Liu CH. Analysis of cell ratio and drug concentration influence in feigning lung cancer model. In 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013. 2013. p. 369-372. 6626779 doi: 10.1109/Transducers.2013.6626779

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abstract = "Here presented is an integrated drug testing system based on a mimetic lung tissue pattern of in vitro targeted therapy testing. The integrated targeted therapy testing system consists of continuous concentration gradient platform and dielectrophoretic (DEP) cell patterning chambers. DEP forces are based on polarity difference to manipulate heterogeneous cells for mimicking the inherent lung morphology and increasing the cell-cell interaction. The multiplexed microchannels allow for simultaneous administration of multiple drug doses to functional lung cancer cells while an incorporated concentration gradient enables the in vitro dose-dependent drug responses to predict in vivo hepatotoxicity.",

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AU - Lee, Kang Yun

AU - Liu, Cheng Hsien

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Analysis of cell ratio and drug concentration influence in feigning lung cancer model

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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